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Table 5 One-way sensitivity analyses: variation of assumptions on costs of productivity, imputed values, and inflation rates

From: Economic burden associated with alcohol dependence in a German primary care sample: a bottom-up study

  Human capital approach Only unimputed costs Annual inflation rate 0 % Annual inflation rate 5 %
Non-AD AD Total Non-AD AD Total Non-AD AD Total Non-AD AD Total
N = 1,213 N = 143 N = 1,356 N = 1,213 N = 143 N = 1,356 N = 1,213 N = 143 N = 1,356 N = 1,213 N = 143 N = 1,356
Direct costs
 Total direct costs excluding alcohol treatment 1 / / / 867.28 (2466.25) 1559.27 (3405.17) **+ 943.07 (2599.48) 800.91 (1950.23) 1371.41 (2715.12) **+ 863.40 (2059.54) 1171.80 (3393.09) 2035.01 (4551.12) **+ 1266.34 (3554.46)
 Total direct costs including alcohol treatment 1 / / / 867.42 (2466.21) 1659.84 (3511.19) ***+ 954.21 (2618.22) 801.06 (1950.18) 1476.12 (2857.76) ***+ 875.00 (2084.39) 1171.96 (3393.04) 2141.91 (4624.28) ***+ 1278.19 (3567.83)
Indirect costs
 Absenteeism 2 941.91 (3004.53) 1893.80 (6667.85) **+ 1046.24 (3626.33) / / / 654.52 (1652.13) 832.67 (2161.33)
*+
674.04 (1718.76) 687.24 (1734.74) 874.31 (2269.40) *+ 707.74 (1804.70)
 Total indirect costs 2 3032.64 (4400.97) 4855.73 (7102.00) ***+ 3232.44 (4820.05) / / / 2738.60 (3766.75) 3784.64 (4073.89) ***+ 2853.25 (3817.31) 2808.17 (3852.92) 3881.61 (4179.12) ***+ 2925.82 (3906.19)
Total costs
 Total costs excluding alcohol treatment 1 3959.68 (5504.37) 6463.50 (9368.64) ***+ 4233.91 (6119.86) 3616.29 (4889.88) 5361.37 (6139.02) ***+ 3807.41 (5077.34) 3537.41 (4582.74) 5156.05 (5629.39) ***+ 3714.69 (4740.96) 3977.80 (5583.99) 5916.62 (7106.93) ***+ 4190.15 (5809.62)
 Total costs including alcohol treatment 1 3959.83 (5504.52) 6568.52 (9442.82) ***+ 4245.54 (6137.20) 3616.43 (4890.06) 5461.94 (6268.48) ***+ 3818.56 (5098.91) 3537.56 (4582.94) 5260.77 (5772.92) ***+ 3726.29 (4764.30) 3977.96 (5584.17) 6023.52 (7212.45) ***+ 4202.00 (5828.11)
  1. Note. All presented costs refer to mean cost per patient with standard deviation in brackets
  2. Imputations mainly affect the prescribed medication section, in addition to inpatient treatment, home care, and alcohol treatment
  3. Significance of excess costs was tested with 1 negative binomial regressions or 2 zero-inflated negative binomial regressions using alcohol dependence and age as predictors in both count (predicting values >0) and logit (predicting 0, only for zero-inflated negative binomial regressions) model. The following symbols indicate a significant AD predictor: count model * p < .05 ** p < .01 *** p < .001; logit model ° p < .05 °° p < .01 °°° p < .001. + or – behind the symbol indicates valence of respective coefficient
  4. AD Alcohol dependence. / = same value as in Table 1, i.e. not affected by human capital approach or by imputations