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Table 3 Odds of having metabolic syndrome. Lifecourse multivariate logistic regression models using data from multiple imputations. Men (N = 3395)

From: The early life nutritional environment and early life stress as potential pathways towards the metabolic syndrome in mid-life? A lifecourse analysis using the 1958 British Birth cohort

 

Model 1

Model 2

Model 3

Model 4

Model 5

OR

CI 95 %

p

OR

CI 95 %

p

OR

CI 95 %

p

OR

CI 95 %

p

OR

CI 95 %

p

Mother’s BMI

 Normal

1

  

1

  

1

  

1

  

1

  

 Underweight

1.06

(0.73–1.53)

0.760

1.06

(0.73–1.53)

0.771

1.05

(0.72–1.52)

0.798

1.11

(0.76–1.62)

0.599

1.13

(0.77–1.65)

0.533

 Overweight

1.31

(1.09–1.57)

0.003

1.30

(1.08–1.56)

0.004

1.29

(1.07–1.54)

0.007

1.24

(1.03–1.50)

0.024

1.24

(1.03–1.49)

0.025

 Obese

1.52

(1.07–2.15)

0.018

1.50

(1.06–2.13)

0.022

1.49

(1.05–2.11)

0.026

1.24

(0.86–1.77)

0.244

1.22

(0.85–1.75)

0.282

Mother’s education level

 Left school at 15 or later

1

  

1

  

1

  

1

  

1

  

 Left school before 14

1.38

(1.16–1.65)

<0.001

1.38

(1.16–1.65)

<0.001

1.36

(1.13–1.63)

0.001

1.34

(1.11–1.61)

0.002

1.34

(1.11–1.61)

0.002

Father’s social class at birth

 Non-manual

1

  

1

  

1

  

1

  

1

  

 Manual

1.25

(1.05–1.49)

0.013

1.25

(1.05–1.49)

0.013

1.23

(1.02–1.47)

0.029

1.17

(0.98–1.41)

0.087

1.18

(0.98–1.42)

0.082

Overcrowding

  > 1.5 personne/chambre

1

  

1

  

1

  

1

  

1

  

  < =1.5 personne/chambre

0.97

(0.77–1.22)

0.775

0.97

(0.77–1.22)

0.789

0.98

(0.77–1.24)

0.842

0.97

(0.76–1.24)

0.805

0.98

(0.77–1.25)

0.882

Birthweight

 Q1 - Low weight

1

  

1

  

1

  

1

  

1

  

 Q2

0.87

(0.70–1.07)

0.187

0.87

(0.71–1.08)

0.204

0.88

(0.71–1.09)

0.229

0.87

(0.70–1.08)

0.207

0.88

(0.71–1.09)

0.239

 Q3

1.02

(0.82–1.27)

0.832

1.03

(0.83–1.28)

0.800

1.04

(0.83–1.29)

0.741

1.01

(0.80–1.26)

0.961

1.01

(0.81–1.27)

0.900

 Q4 - High weight

0.90

(0.72–1.14)

0.390

0.91

(0.73–1.15)

0.430

0.92

(0.73–1.16)

0.471

0.84

(0.66–1.07)

0.151

0.84

(0.66–1.07)

0.161

Mother smoked during pregnancy

 No

1

  

1

  

1

  

1

  

1

  

 Sometimes

1.16

(0.87–1.56)

0.308

1.16

(0.86–1.55)

0.328

1.14

(0.85–1.53)

0.389

1.07

(0.79–1.45)

0.644

1.07

(0.79–1.45)

0.645

 Moderately

1.12

(0.91–1.38)

0.268

1.12

(0.91–1.38)

0.272

1.12

(0.91–1.38)

0.286

1.06

(0.86–1.31)

0.594

1.06

(0.86–1.31)

0.576

 Heavily

0.98

(0.78–1.24)

0.878

0.97

(0.77–1.23)

0.824

0.95

(0.75–1.20)

0.639

0.90

(0.70–1.14)

0.371

0.89

(0.70–1.14)

0.361

Mother’s age at birth

 23 years or less

1

  

1

  

1

  

1

  

1

  

 24 to 27 years

1.09

(0.90–1.33)

0.377

1.09

(0.90–1.33)

0.381

1.10

(0.90–1.35)

0.335

1.11

(0.91–1.36)

0.300

1.12

(0.91–1.37)

0.274

 28 to 31 years

1.01

(0.82–1.26)

0.894

1.02

(0.82–1.27)

0.879

1.04

(0.83–1.30)

0.719

1.05

(0.83–1.31)

0.697

1.04

(0.83–1.31)

0.712

 32 years or more

0.83

(0.66–1.05)

0.119

0.84

(0.66–1.06)

0.134

0.86

(0.68–1.09)

0.209

0.85

(0.66–1.08)

0.179

0.85

(0.66–1.08)

0.182

Breastfed

 No

1

  

1

  

1

  

1

  

1

  

 Yes, for less than 1 month

1.02

(0.83–1.24)

0.877

1.01

(0.83–1.24)

0.887

1.01

(0.83–1.24)

0.913

1.02

(0.83–1.26)

0.852

1.02

(0.83–1.26)

0.863

 Yes, more than 1 month

1.00

(0.84–1.19)

0.993

1.00

(0.84–1.19)

0.995

1.01

(0.84–1.20)

0.934

1.03

(0.86–1.22)

0.781

1.03

(0.86–1.23)

0.780

Parity

 Oldest child

1

  

1

  

1

  

1

  

1

  

 2nd child

0.88

(0.74–1.05)

0.168

0.88

(0.74–1.05)

0.159

0.87

(0.73–1.04)

0.132

0.88

(0.73–1.05)

0.165

0.87

(0.73–1.05)

0.148

 3rd child or more

1.00

(0.82–1.23)

0.965

1.00

(0.81–1.22)

0.973

0.97

(0.78–1.19)

0.747

0.99

(0.80–1.23)

0.946

0.99

(0.80–1.23)

0.924

Gestational age

 38 weeks or less

1

  

1

  

1

  

1

  

1

  

 39 to 41 weeks

1.19

(0.89–1.60)

0.248

1.19

(0.88–1.60)

0.253

1.21

(0.90–1.62)

0.215

1.17

(0.87–1.57)

0.295

1.18

(0.87–1.60)

0.284

 42 weeks or more

1.18

(0.85–1.62)

0.323

1.17

(0.85–1.61)

0.331

1.18

(0.86–1.63)

0.299

1.17

(0.86–1.61)

0.318

1.19

(0.86–1.63)

0.297

Type of delivery

 Vaginal

1

  

1

  

1

  

1

  

1

  

 Emergency caesarean

1.86

(1.06–3.29)

0.032

1.83

(1.03–3.23)

0.038

1.83

(1.03–3.25)

0.038

1.98

(1.11–3.56)

0.022

2.02

(1.13–3.63)

0.018

 Elective caesarean

0.73

(0.37–1.44)

0.359

0.73

(0.37–1.44)

0.361

0.77

(0.39–1.54)

0.465

0.75

(0.37–1.50)

0.412

0.75

(0.37–1.51)

0.423

Adverse childhood experiences

 None

   

1

  

1

  

1

  

1

  

 One

   

0.93

(0.78–1.12)

0.452

0.91

(0.76–1.09)

0.296

0.91

(0.76–1.10)

0.331

0.91

(0.76–1.10)

0.341

 Two or more

   

1.19

(0.89–1.59)

0.243

1.12

(0.83–1.50)

0.469

1.18

(0.87–1.59)

0.294

1.16

(0.86–1.57)

0.340

Smoking status at 23

 Non-smoker

      

1

  

1

  

1

  

 Former smoker

      

0.95

(0.78–1.15)

0.575

0.94

(0.77–1.15)

0.541

0.94

(0.77–1.14)

0.521

 Smoker - Less than 10 cig.

      

1.13

(0.82–1.56)

0.438

1.15

(0.82–1.60)

0.414

1.15

(0.82–1.60)

0.424

 Smoker - 10 to 19 cig.

      

0.95

(0.74–1.22)

0.685

0.98

(0.76–1.27)

0.883

0.97

(0.76–1.26)

0.839

 Smoker - More than 20 cig.

      

1.11

(0.88–1.40)

0.378

1.13

(0.90–1.44)

0.295

1.13

(0.89–1.44)

0.304

Alcohol consumption at 23

 Moderate

      

1

  

1

  

1

  

 Abstainers

      

1.00

(0.76–1.31)

0.991

1.02

(0.77–1.35)

0.893

0.99

(0.75–1.31)

0.937

 Heavy drinkers

      

1.08

(0.91–1.27)

0.368

1.06

(0.90–1.26)

0.497

1.06

(0.89–1.25)

0.521

Physical activity at 23

 Physically active

      

1

  

1

  

1

  

 Moderately active

      

1.13

(0.91–1.40)

0.259

1.13

(0.91–1.40)

0.283

1.12

(0.90–1.40)

0.297

 Inactive

      

1.25

(1.04–1.52)

0.020

1.25

(1.03–1.53)

0.026

1.25

(1.02–1.52)

0.029

Malaise inventory at 23

 No

      

1

  

1

  

1

  

 Yes

      

1.30

(0.87–1.94)

0.200

1.28

(0.85–1.94)

0.237

1.30

(0.86–1.97)

0.218

Education level at 23

 Passed A levels

      

1

  

1

  

1

  

 Passed O levels

      

1.04

(0.84–1.31)

0.705

0.98

(0.79–1.23)

0.893

1.00

(0.78–1.28)

0.991

 No qualifications

      

1.12

(0.88–1.43)

0.356

0.99

(0.77–1.26)

0.913

1.00

(0.75–1.34)

0.986

BMI at 23

 Normal

         

1

  

1

  

 Underweight

         

0.52

(0.28–0.96)

0.036

0.50

(0.27–0.93)

0.028

 Overweight

         

2.27

(1.83–2.82)

<0.001

2.27

(1.83–2.82)

<0.001

 Obese

         

3.52

(1.92–6.46)

<0.001

3.43

(1.87–6.31)

<0.001

Occupational social class at 33

 Non-manual

            

1

  

 Manual

            

0.94

(0.77–1.14)

0.516

Wealth at 33

 Not owner

            

1

  

 Owner - Q1 (Low price)

            

0.79

(0.62–1.01)

0.062

 Owner - Q2

            

0.83

(0.65–1.06)

0.131

 Owner - Q3

            

0.83

(0.64–1.07)

0.145

 Owner - Q4

            

0.78

(0.60–1.02)

0.066

Marital status at 33

 Couple

            

1

  

 Single

            

0.96

(0.76–1.20)

0.709

 Divorced or widowed

            

0.69

(0.47–1.00)

0.050

  1. Model 1 included mother’s pre-pregnancy BMI and all variables measured at or around birth; Model 2: Model 1 + ACE; Model 3: Model 2 + potential mediators measured at 23 years except for participants’ BMI at 23 years; Model 4: Model 3 + participant’s BMI at 23 years; Model 5: Full model