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Table 5 Change in blood pressure medication and physiologic outcomes at 12 monthsa

From: A community-based lifestyle and weight loss intervention promoting a Mediterranean-style diet pattern evaluated in the stroke belt of North Carolina: the Heart Healthy Lenoir Project

Outcome Phase 2
6 months to 12 months Baseline to 12 months
(12 months minus 6 months) (12 months minus baseline)
n Mean, 95 % CI n Mean, 95 % CI
Blood Pressure Medication
Taking BP lowering medication, %
 All 221 −0.5 % (−2.8 to 1.9) 253 0.0 % (−3.3 to 3.3)
  --African American 153 0.0 % (−3.1 to 3.1) 178 −0.6 % (−4.5 to 3.4)
  --White 66 −1.5 % (−4.5 to 1.4) 73 1.4 % (−4.6 to 7.4)
   --Lifestyle 95 −1.0 % (−3.1 to 1.0) 127 −0.8 % (−5.4 to 3.8)
   --Wt loss, group 51 −2.0 % (−8.6 to 4.7) 51 −2.0 % (−10.5 to 6.6)
   --Wt loss, combination 75 1.3 % (−3.2 to 5.8) 75 2.7 % (−2.5 to 7.9)
Physiologic
Systolic BP, mm Hg
 LS study only 99 3.2 (0.3 to 6.2) * 101 −1.4 (−4.5 to 1.6)
 LS and HBP study 121 −2.5 (−6.5 to 1.4) 150 −9.3 (−13.6 to −5.1) ***
 All 220 0.0 (−2.5 to 2.6) 251 −6.1 (−9.0 to −3.3) ***
  Subgroup by raceb     
  --African American 152 −0.9 (−4.0 to 2.1) 176 −6.9 (−10.5 to −3.3) ***
  --White 66 2.5 (−2.5 to 7.4) 73 −4.2 (−8.8 to 0.3)
  Subgroup by interventionc     
   --Lifestyle 95 −2.2 (−6.2 to 1.8) 126 −8.3 (−12.6 to −3.9) ***
   --Wt loss, group 50 3.3 (−1.0 to 7.6) 50 −3.6 (−7.8 to 0.5)
   --Wt loss, combination 75 0.7 (−3.8 to 5.3) 75 −4.3 (−9.7 to 1.1)
Diastolic BP, mm Hg
 LS study only 99 0.4 (−1.4 to 2.2) 101 −2.0 (−3.7 to −0.4) *
 LS and HBP study 121 −3.1 (−5.3 to −1.0) ** 150 −7.0 (−9.0 to −4.9) ***
 All 220 −1.5 (−2.9 to −0.1) * 251 −5.0 (−6.4 to −3.6) ***
  --African American 152 −2.3 (−4.0 to −0.5) ** 176 −5.2 (−7.0 to −3.4) ***
  --White 66 0.7 (−1.8 to 3.2) 73 −4.2 (−6.4 to −1.9) ***
   --Lifestyle 95 −2.2 (−4.4 to 0.1) 126 −5.4 (−7.5 to −3.2) ***
   --Wt loss, group 50 1.2 (−1.0 to 3.4) 50 −4.2 (−6.9 to −1.6) **
   --Wt loss, combination 75 −2.5 (−5.1 to 0.1) 75 −4.5 (−7.2 to −2.3) ***
Weight, kg
 All 219 −1.1 (−1.7 to −0.5) *** 250 −1.7 (−2.5 to 1.0) ***
  --African American 151 −0.9 (−1.6 to −0.3) ** 175 −1.7 (−2.6 to −0.8) ***
  --White 66 −1.4 (−2.3 to −0.3) * 73 −1.6 (−3.1 to −0.2) *
--Lifestyle 94 −0.3 (−1.3 to 0.6) 125 −0.9 (−2.1 to 0.2)
--Wt loss, group 50 −1.3 (−2.4 to −0.2) * 50 −3.1 (−4.9 to −1.3) ***
--Wt loss, combination 75 −1.9 (−2.8 to −1.0) *** 75 −2.1 (−3.2 to −1.0) ***
Weight, ≥ 5 % weight loss, %
 All 219 18 % (13 to 23) 250 23 % (18 to 28)
  --African American 151 18 % (12 to 24) 175 23 % (17 to 30)
  --White 66 18 % (9 to 28) 73 22 % (12 to 31)
   --Lifestyle 94 14 % (7 to 21) 125 19 % (12 to 26)
   --Wt loss, group 50 22 % (10 to 34 50 34 % (21 to 47)
   --Wt loss, combination 75 21 % (12 to 31) 75 23 % (13 to 32)
Total cholesterol, mg/dLd
 All    221 −3 (−7.0 to 0.7)
  --African American    155 −4 (−8.5 to 0.4)
  --White    64 0 (−7.8 to 7.7)
   --Lifestyle    106 −3 (−9.1 to 2.7)
   --Wt loss, group    44 −6 (−13.5 to 1.4)
   --Wt loss, combination    71 −1 (−8.0 to 5.2)
HDL cholesterol, mg/dL
 All    220 −2 (−2.8 to −0.4) **
  --African American    154 −2 (−3.0 to 0) *
  --White    64 −2 (−3.8 to 0.3)
   --Lifestyle    106 −2 (−3.8 to −0.1)
   --Wt loss, group    44 −1 (−3.1 to 1.5)
   --Wt loss, combination    70 −1 (−3.5 to 0.5)
  1. Abbreviations: BP blood pressure, CI confidence interval, HBP high blood pressure, LS lifestyle
  2. Note: Boldface indicates statistical significance *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.
  3. SI unit conversion factors: To convert all types of cholesterol to millimoles per liter, multiply by 0.0259
  4. a Data are means except where noted
  5. b 3 categorized as other race
  6. c Participants selected intervention group at 6 month follow-up visit; if they did not attend this visit they were assigned to lifestyle group
  7. d To convert from mg/dL to mmol/L divide by 68.37