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Table 3 Summary of the number of cigarettes smoked and estimated amount of nicotine delivered

From: Reductions in biomarkers of exposure, impacts on smoking urge and assessment of product use and tolerability in adult smokers following partial or complete substitution of cigarettes with electronic cigarettes

  

Exclusive e-Cigarette use

Dual use

Nicotine cessation

 

Tobacco rechargeable

Cherry rechargeable

Cherry disposable

Tobacco rechargeable

Cherry rechargeable

Cherry disposable

-

Screening

Cigarettes

18.4 ± 7.1

17.3 ± 6.2

15.4 ± 3.3

18.7 ± 6.6

20.5 ± 7.3

21.1 ± 5.8

20.4 ± 7.5

   Day −1

Cigarettes

16.9 ± 5.1

15.8 ± 5.4

14.9 ± 1.5

14.5 ± 4.5

14.2 ± 2.0

14.8 ± 2.4

17.5 ± 4.9

   Day 1

Cigarettes

NA

NA

NA

8.9 ± 3.1

9.6 ± 2.7

9.8 ± 2.0

NA

 

E-cigarette nicotine

14.9 ± 15.2

17.7 ± 16.9

13.6 ± 11.0

8.9 ± 6.9

4.6 ± 3.3

5.6 ± 3.4

NA

   Day 2

Cigarettes

NA

NA

NA

8.9 ± 2.9

9.5 ± 2.8

9.9 ± 1.9

NA

 

E-cigarette nicotine

17.2 ± 15.1

17.6 ± 14.3

19.6 ± 16.8

11.1 ± 7.8

6.5 ± 5.5

7.4 ± 7.2

NA

   Day 3

Cigarettes

NA

NA

NA

8.9 ± 3.0

9.5 ± 2.5

10.1 ± 2.0

NA

 

E-cigarette nicotine

16.3 ± 13.4

19.8 ± 16.9

19.4 ± 20.0

12.4 ± 9.5

6.2 ± 6.5

9.4 ± 9.8

NA

   Day 4

Cigarettes

NA

NA

NA

9.0 ± 3.2

9.7 ± 2.9

10.0 ± 2.0

NA

 

E-cigarette nicotine

18.4 ± 14.6

20.8 ± 14.2

23.4 ± 21.0

13.3 ± 10.7

7.5 ± 8.3

9.9 ± 9.1

NA

   Day 5

Cigarettes

NA

NA

NA

9.0 ± 3.3

9.6 ± 2.8

10.4 ± 2.2

NA

 

E-cigarette nicotine

19.4 ± 16.6

22.9 ± 16.6

22.9 ± 20.5

12.7 ± 11.6

7.0 ± 9.3

9.1 ± 8.6

NA

   Day 1 through Day 5 Mean

Cigarettes

NA

NA

NA

44.7 ± 15.4

47.9 ± 13.6

50.5 ± 9.5

NA

E-cigarette nicotine

86.1 ± 70.5

98.9 ± 75.1

99.0 ± 86.8

61.8 ± 45.9

31.9 ± 30.1

38.9 ± 36.4

NA

  1. Values are presented as mean ± SD mg nicotine or cigarettes smoked
  2. Cessation group subjects reported smoking 20.4 ± 7.5 CPD during screening and smoked 17.5 ± 4.9 cigarettes on Day −1
  3. NA Not available