Reductions in biomarkers of exposure, impacts on smoking urge and assessment of product use and tolerability in adult smokers following partial or complete substitution of cigarettes with electronic cigarettes

Table 11 Day 5 evening and day 5 evening change from morning smoking urge statistical comparisons between use groups

Comparison	Day 5 evening comparisons				Day 5 evening change from morning comparisons
Comparison	First LSM (%)	Second LSM (%)	Difference (%)	p-Value	First LSM (%)	Second LSM (%)	Difference (%)	p-Value
A1 vs C	63.00	66.32	−3.32	0.7589	−8.92	2.69	−11.61	0.2273
A2 vs C	43.32	66.32	−23.00	*0.0355*	−10.05	2.69	−12.75	0.1818
A3 vs C	49.91	66.32	−16.41	0.1323	−16.90	2.69	−19.59	*0.0427*
B1 vs C	45.74	66.32	−20.58	0.0611	−16.84	2.69	−19.53	*0.0443*
B2 vs C	37.69	66.32	−28.63	*0.0094*	−29.06	2.69	−31.75	*0.0012*
B3 vs C	40.90	66.32	−25.42	*0.0229*	−28.97	2.69	−31.66	*0.0014*
A1 vs B1	63.00	45.74	17.26	0.1111	−8.92	−16.84	7.92	0.4066
A2 vs B2	43.32	37.69	5.63	0.5971	−10.05	−29.06	19.00	*0.0401*
A3 vs B3	49.91	40.90	9.01	0.4108	−16.90	−28.97	12.07	0.2015
A1 vs A2	63.00	43.32	19.68	0.0668	−8.92	−10.05	1.14	0.9016
A1 vs A3	63.00	49.91	13.09	0.2226	−8.92	−16.90	7.98	0.3982
A2 vs A3	43.32	49.91	−6.58	0.5364	−10.05	−16.90	6.84	0.4594
B1 vs B2	45.74	37.69	8.05	0.4562	−16.84	−29.06	12.22	0.1921
B1 vs B3	45.74	40.90	4.84	0.6608	−16.84	−28.97	12.13	0.2019
B2 vs B3	37.69	40.90	−3.21	0.7664	−29.06	−28.97	−0.09	0.9921

LSM Least-square means
Use Groups
A1: Exclusive Tobacco flavor rechargeable e-cigarette
A2: Exclusive Cherry flavor rechargeable e-cigarette
A3: Exclusive Cherry flavor disposable e-cigarette
B1: Dual Classic Tobacco flavor rechargeable e-cigarette and a usual brand combustible cigarette
B2: Dual Cherry flavor rechargeable e-cigarette and a usual brand combustible cigarette
B3: Dual Cherry flavor disposable e-cigarette and a usual brand combustible cigarette
C: Nicotine cessation
p-values indicate statistically significant

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