LInking EDCs in maternal Nutrition to Child health (LINC study) – protocol for prospective cohort to study early life exposure to environmental chemicals and child health

de Cock, Marijke; Quaak, Ilona; Sugeng, Eva J.; Legler, Juliette; van de Bor, Margot

doi:10.1186/s12889-016-2820-8

Table 1 Measurements in LINC during pregnancy and the first 18 months after birth

From: LInking EDCs in maternal Nutrition to Child health (LINC study) – protocol for prospective cohort to study early life exposure to environmental chemicals and child health

Time	Exposure	Anthropometry	Behavioral and cognitive development	Determinants of exposure	Other (questionnaires)
1^st trimester of pregnancy		Weight (mother, and father)		Maternal diet before pregnancy (FFQ)	Demographics
		Length (mother and father)		Occupational and residential exposure	Previous pregnancies, fertility
					Allergies (mother and father)
					Lifestyle
					Mental state, stress (mother)
2^nd trimester of pregnancy				Maternal diet during pregnancy (food diary)	Lifestyle
2^nd trimester of pregnancy				Maternal diet during pregnancy (food diary)	Mental state, stress
3^rd trimester of pregnancy		Weight (mother, 36 weeks of gestation)			General health, medication, family history
					Lifestyle
					Mental state, stress (mother)
					Social support (mother)
Birth	Cord blood	Birth weight
	Placenta	Head and waist circumference
	Vernix
	Heel prick blood
	Meconium
	Urine (1^st week)
Month 1		Weight and length	van Wiechen Scheme
Month 1		Head circumference	van Wiechen Scheme
Month 2	Breast milk	Weight and length	van Wiechen Scheme
Month 2	Breast milk	Head circumference	van Wiechen Scheme
Month 3		Weight and length	van Wiechen Scheme		Infant diet
		Head circumference			Second hand smoke exposure
					Mental state, stress (mother)
					Crying/sleeping pattern
Month 4		Weight and length	van Wiechen Scheme
Month 4		Head circumference	van Wiechen Scheme
Month 6		Weight and length	van Wiechen Scheme	Occupational and residential exposure	Infant diet
		Head circumference			Second hand smoke exposure
					Mental state, stress (mother)
					Social support (mother)
					Crying/sleeping pattern
Month 9		Weight and length	van Wiechen Scheme		Infant diet
		Head circumference			Second hand smoke exposure
					Mental state, stress (mother)
					Crying/sleeping pattern
Month 12	Saliva	Weight and length	van Wiechen Scheme	Hand, back, and mouth wipe	Infant diet
		Head circumference	Child behavior (infant behavior questionnaire)	Dust sample	Child allergies
				Occupational and residential exposure	Second hand smoke exposure
				Hand-to-mouth behavior child	Mental state, stress (mother)
				Hand-to-mouth behavior child	Crying/sleeping pattern
Month 18			van Wiechen Scheme		Second hand smoke exposure
			Child behavior (child behavior checklist)		Mental state, stress (mother)
			Child behavior (child behavior checklist)		Crying/sleeping pattern

All measurements are collected from the child, unless mentioned otherwise

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ISSN: 1471-2458

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