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Table 4 Odds ratios between lung cancer and selected chemical agents in analyses restricted to construction workers, in the pooled set of studies, stratified by smoking status, and test for interaction

From: Lung cancer risk among workers in the construction industry: results from two case–control studies in Montreal

Chemical agenta

Smoking status

P-valueg

Never-low smokers (n = 229)

Medium-heavy smokers (n = 506)

Never exposedc

Ca/Cod

ORe

95 % CIf

Never exposedc

Ca/Co

ORe

95 % CI

Soil dust

         

Ever exposed

41/80

23/85

1.1

0.6–2.1

196/91

154/65

1.1

0.8–1.5

0,9687

Substantially exposedb

 

13/18

2.9

1.0–8.9

 

63/14

1.8

0.9–3.6

0,8496

Asbestos

         

Ever exposed

44/113

20/52

1.2

0.7–2.2

248/111

102/45

1.1

0.8–1.6

0,6778

Substantially exposed

 

5/5

2.3

0.4–14.5

 

20/7

1.8

0.7–4.9

0,7166

Crystalline silica

         

Ever exposed

29/80

35/85

1.0

0.6–1.7

141/79

209/77

1.3

0.9–1.7

0,2623

Substantially exposed

 

17/18

3.1

1.0–9.6

 

54/19

1.4

0.7–2.7

0,0223

Portland cement

         

Ever exposed

42/110

22/55

1.4

0.8–2.5

241/105

109/51

1.0

0.7–1.4

0,3067

Substantially exposed

 

13/14

4.0

1.2–13.4

 

39/13

1.3

0.6–2.8

0,4819

Calcium oxide

         

Ever exposed

52/147

12/18

1.8

0.8–3.7

300/130

50/26

1.0

0.6–1.4

0,1193

Substantially exposed

 

9/10

3.2

0.9–12.0

 

27/8

1.7

0.7–4.1

0,5410

Calcium sulfate

         

Ever exposed

36/95

28/70

1.0

0.6–1.8

191/92

159/64

1.2

0.9–1.6

0,8699

Substantially exposed

 

14/22

1.3

0.5–3.6

 

62/22

1.6

0.9–2.9

0,9670

  1. aCriteria for selection of chemical agents: at least ten cases or ten controls with substantial exposure in the pooled studies; prevalence of exposure greater than 5 % among construction workers; and prevalence among controls at least twice as high in construction workers as in other workers
  2. bSubstantial exposure comprised subjects who had been exposed with a probable or definite reliability to medium or high concentrations for more than 5 % of their workweek and for at least 5 years
  3. cFor each chemical agent, the reference category consists of construction workers who were never exposed to the agent
  4. dNumber of cases/number of controls substantially exposed
  5. eOR Odds ratio adjusted for age, median family income for census tract, comprehensive smoking index, respondent status, education level and ethnicity and binary indicator for study
  6. f95 % confidence interval
  7. gSignificance of the interaction term between smoking (binary) and occupational exposure (1) ever vs never exposed or 2) not exposed/not substantially exposed/substantially exposed, in the regression models