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Table 1 Baseline characteristic of studies included

From: Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies

Study Country Sex Study design Sample size Age at baseline Ex-drinker (%) Light alcohol (%) Moderate alcohol (%) Heavy alcohol (%) Follow-up (year) Main outcomes NOS score
Framingham [24] US Men Cohort 3871 >50 19.9 30.0 14.7 35.4 10.0 Ischemic stroke 8
Women Cohort 5300 >50 37.9 39.1 9.6 13.4
DANCOS [8] Denmark Men Cohort 12994 19–75 14.4 27.8 41.5 16.3 6.9 Coronary disease, total mortality 7
Women Cohort 13794 20–79 27.9 39.8 28.8 3.8
EPOZ [25] Netherlands Men Cohort 760 - 6.7 17.6 38.6 37.1 10.0 Cardiac death, total mortality 6
Women Cohort 860 - 18.4 29.3 34.9 17.4
MPC [10] US Men Cohort 13870 >30 60.9 14.4 10.0 12.8 20.0 Coronary disease, stroke, total mortality 7
Women Cohort 13808 >30 85.6 8.4 3.2 2.2
NHEFS [26] US Men Cohort 768 46.3 17.8 63.8 7.0 11.5 17.0 Total mortality 5
Women Cohort 1286 45.7 36.7 56.5 3.2 3.7
Whitehall II [27] UK Men Cohort 6840 35–55 13.0 45.6 12.6 28.7 11.0 Coronary disease, total mortality 7
Women Cohort 3374 35–55 29.1 54.8 11.4 4.7
MONICA/KORA-Augsburg [28] Germany Men Cohort 1345 35–64 7.4 19.7 23.8 34.5 10.1 Total mortality 7
Women Cohort 1365 35–64 28.3 30.0 15.8 -
MCCS [9] Australia Men Cohort 15156 40–69 13.2 39.9 20.8 16.1 11.4 Coronary disease 8
Women Cohort 23044 40–69 38.3 37.3 11.0 -
CCHS [29] Denmark Men Cohort 5272 >20 15.3 - 51.0 33.7 20.0 Coronary disease, total mortality 9
Women Cohort 6642 >20 42.8 - 50.4 6.8
HPFS and NHS [30] US Men Cohort 43685 54 - - - - 18-20 Total stroke, ischemic stroke 6
Women Cohort 71243 50 - - - -
LWCS [31] US Men Cohort 4852 74 21.6 24.9 27.0 26.5 12.0 Cardiac death 7
Women Cohort 8444 73 27.7 35.4 21.3 15.7
DDCHS [32, 33] Denmark Men Cohort 26035 50–65 4.9 52.3 11.9 30.9 5.7 Coronary disease 8
Women Cohort 29427 50–65 15.8 66.0 9.2 9.0
JACC [3436] Japan Men Cohort 34776 40–79 22.5 17.6 23.2 29.9 14.2 Cardiac death, total mortality, stroke, ischemic stroke 9
Women Cohort 48906 40–79 83.5 12.0 2.1 0.7
EPIC-Nutrition-Heidelberg [37] Germany Men Cohort 11062 42–62 30.0 31.0 30.0 9.0 12.0 Total stroke 7
Women Cohort 12865 37–62 60.0 22.0 13.0 5.0
EPIC-Potsdam [38] Germany Men Nested case-cohort 815 35–65 3.2 33.4 24.5 38.9 8.2 Coronary disease, stroke 6
Women Nested case-cohort 1360 35–65 2.6 81.9 14.1 7.4
EPIC-Spanish [39] Spain Men Cohort 15630 29–69 4.0 13.5 32.6 41.3 10.0 Coronary disease 7
Women Cohort 25808 29–69 35.1 33.8 21.3 3.0
Lifestyle and health study [40, 41] Netherlands Men Nested case-cohort 1961 45–70 - - - - 5.0 Coronary disease, total mortality 5
Women Nested case-cohort 1713 45–70 - - - -
NHIS [42, 43] US Men Cohort 10998 >18 - 23.0 30.0 47.0 14.0 Cardiac death, total mortality 8
Women Cohort 9767 >18 - 33.3 36.6 31.1