Table 2 Factors associated with reported adverse events in 228 exposed HCWs/HCSs on HIV post-exposure prophylaxis
Characteristic | Adverse events status1 | Crude hazard ratio [95 % CI] | p-value | Adjusted hazard ratio [95 % CI] | p-value | |
|---|---|---|---|---|---|---|
Present | Absent | |||||
Drug regimen | ||||||
3TC/AZT −28 days | 68 | 7 | 1.00 | 1.00 | ||
3TC/AZT-3 days | 28 | 73 | 0.31 [0.20–0.48] | <0.001 | 0.30 [0.18–0.48] | <0.001 |
3TC/AZT/LPV-RTV-28 days | 50 | 2 | 1.06 [0.74–1.53] | 0.752 | 1.06 [0.65–1.72] | 0.817 |
Gender | - | |||||
Female | 81 | 50 | 1.00 | |||
Male | 65 | 32 | 1.08 [0.78–1.50] | 0.629 | ||
Type of exposure | - | |||||
Percutaneous | 131 | 80 | 1.00 | |||
Mucocutaneous | 15 | 2 | 1.42 [0.83–2.43] | 0.197 | ||
Age category (yrs) | - | |||||
18–30 | 101 | 60 | 1.00 | |||
31–40 | 32 | 18 | 1.02 [0.69–1.52] | 0.921 | ||
41–50 | 8 | 2 | 1.28 [0.62–2.62] | 0.508 | ||
>51 | 5 | 2 | 1.14 [0.46–2.80] | 0.777 | ||
Risk assessment | ||||||
Low | 51 | 63 | 1.00 | 1.00 | ||
Medium | 40 | 16 | 1.60 [1.06–2.42] | 0.027 | 0.95 [0.61–1.49] | 0.885 |
High | 55 | 3 | 2.12 [1.45–3.10] | <0.001 | 0.97 [0.57–1.66] | 0.922 |
Profession | - | |||||
Nurses | 51 | 31 | 1.00 | |||
HCS | 14 | 10 | 0.94 [0.52–1.69] | 0.832 | ||
Laboratory Staff | 15 | 1 | 1.51 [0.85–2.68] | 0.162 | ||
Medical Doctors | 46 | 31 | 0.96 [0.65–1.43] | 0.843 | ||
Ward Attendants | 20 | 9 | 1.11 [0.66–1.86] | 0.695 | ||