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Table 2 Vaccine characteristics and immunisation strategies considered in the models evaluating routine varicella vaccination

From: Systematic review of models assessing the economic value of routine varicella and herpes zoster vaccination in high-income countries

Study

Age at vaccination

Vaccine efficacy

Waning (per year)

Vaccination coverage

Vaccination costs per dose (2010 EUR; German price level)

Banz et al. [35]

15 months; 11–12 years

86 %

0.5 %

85 % (children); 30 % (adolescents)

EUR 65.93 (children)a; EUR 71.38 (adolescents)a

Banz et al. [51]

1-2 years; 11–15 years

95 %

0.5 %

70 % (children); 85 % (adolescents)

EUR 42.20 (children)a; EUR 56.65 (adolescents)a

Beutels et al. [37]

15 months; 12 years

90 %

Waning in 15 % of the protected vaccineesb

70 %

EUR 50.82a

Bilcke et al. [30]

1 year (1st dose); 4, 6 or 11 years (2nd dose)

Data from van Hoek et al. 2012

Data from van Hoek et al. 2012

50 % or 95 % (1st dose); 50 %, 80 % or 90 % (2nd dose)

EUR 44.92a

Bonanni et al. [36]

12-18 months; 13 years

90 % (1st dose); 93 % (2nd dose)

3 %

85 %

EUR 46.81a,c

Brisson et al. [31]

12 months; 12 years

93 %

3.1 %

90 % (infants); 80 % (adolescents)

EUR 51.42 (children)a; EUR 68.57 (adolescents)a

Brisson et al. [32]

Infants; 11 years

93 %

3.1 %

90 % (infants); 80 % (adolescents)

EUR 44.32 (children)a; EUR 59.10 (adolescents)a

Coudeville et al. [52]

<6 years

90 %

Waning in 15 % of the protected vaccineesb

80 %

EUR 18.11c,d

Coudeville et al. [53]

12-36 months

97 %

3.1 %

45 %-90 %

EUR 52.00a,c

Coudeville et al. [54]

12-36 months

97 %

3.1 %

45 %-90 %

EUR 64.08 (Germany)a,c; EUR 59.56 (France)a,c

Diez Domingo et al. [55]

15 months

90 %

No waning

95 %

EUR 37.11

Getsios et al. [56]

12 months

90 %

Waning in 15 % of the protected vaccineesb

85 %

EUR 60.25a,d

Ginsberg & Somekh [57]

12 months

87.6 %

3.1 %

94 %

EUR 8.01a,c,d

Hammerschmidt et al. [58]

11-23 months (catch-up of 2–17 year olds)

86 % (1-dose schedule); 95 % (2-dose schedule)

0.5 %

90 % (1st dose); 80 % (2nd dose); 30 % (catch-up); 10 % (comparator)

EUR 47.38 (monovalent vaccine); EUR 47.92 (varicella-attributable cost of the MMRV vaccine)

Huse et al. [59]

15 months

95 %

No waning

Not specified

EUR 62.31a

Lenne et al. [60]

1-2 years

97 %

3,1 %

97,15 %

EUR 42.54a

Lieu et al. [61]

<6 years

90 %

Waning in 15 % of the protected vaccineesb

97 %

EUR 54.12a

Preblud et al. [62]

15 months

90 %

No waning

90 %

EUR 25.53

Scuffham et al. [63]

15 months

95 %

No waning

80 %; 10 % (comparator)

EUR 45.94

Scuffham et al. [34]

12 months; 12 years

95 %

No waning

80 % (infants); 50-75 % (adolescents)

EUR 42.26

Thiry et al. [64]

11 years

93,12 %

3.1 %

60 %

EUR 52.36a

van Hoek et al. [33]

1 year (1st dose); 3 years (2nd dose)

89-96 % (1st dose); 93-96 % (2nd dose)

1.5-6.7 % (1st dose); 0.05-2.6 % (2nd dose)

90 % (1st dose); 80 % (2nd dose)

EUR 41.19

Zhou et al. [29]

Children

80 % (1-dose schedule)e; 93 % (2-dose schedule)

No waning

Age-specific coverage rates; 95 % (2nd dose)

EUR 49.90 (monovalent vaccine)f; EUR 65.64 (MMRV vaccine)f

  1. MMRV measles, mumps, rubella and varicella
  2. aIncluding administration costs
  3. bWaning rate per year not quantified
  4. cIncluding costs of treating adverse events
  5. dIncluding vaccine wastage
  6. eThis efficacy estimate was not directly used in the model; the vaccine-induced reduction in incidence was calculated by using age-specific surveillance data
  7. fPublic sector price