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Table 4 Variables associated with DALY losses adjusted by risk factors

From: Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study

Variables*

ANCOVAa

MANCOVAb

Undiscounted DALYs

Constant

(95% CI)

P-value

Constant

(95% CI)

P-value

Mean

(95% CI)

P-value

BMD

0.1

(0.0, 0.3)

0.066

0.2

(0.1, 0.3)

0.004

-

-

-

Prior osteoporosis BF (No)

−2.0

(−2.5, −1.4)

<0.001

−1.8

(−2.3, −1.2)

<0.001

-

-

-

BMI < 20 kg/m2 (No)

0.0

(−0.7, 0.8)

0.898

-

-

-

6.1

(5.2, 6.9)

-

Smoking status (Non-smoker)

−0.2

(−0.7, 0.2)

0.336

-

-

-

6.0

(5.9, 6.2)

-

Alcohol consumption ≥30 g/day (No)

−2.4

(−4.0, −0.8)

0.003

-

-

-

6.2

(5.9, 6.0)

P < 0.01

Rheumatoid arthritis (No)

−2.9

(−3.6, −2.1)

<0.001

−2.8

(−3.5, −2.0)

<0.001

5.9

(5.8, 6.1)

P < 0.01

Family antecedents of osteoporosis (No)

−0.4

(−0.7, 0.0)

0.033

−0.4

(−0.8, −0.1)

0.016

5.8

(5.6, 6.0)

P < 0.05

Use of corticosteroids (No)

−3.6

(−5.9, −1.4)

0.002

−3.6

(−5.9, −1.2)

0.003

6.0

(5.9, 6.2)

P < 0.01

Variables

ANCOVA a

MANCOVA b

Undiscounted DALYs

Constant

(95% CI)

P -value

Constant

(95% CI)

P -value

Mean

(95% CI)

P -value

BMD

0.1

(0.0, 0.2)

0.102

0.1

(0.0, 0.2)

0.004

-

-

-

Prior osteoporosis BF (No)

−1.5

(−1.8, −1.1)

<0.001

−1.4

(−1.8, −1.1)

<0.001

-

-

-

BMI < 20 kg/m2 (No)

0.2

(−0.3, 0.7)

0.462

-

-

-

4.1

3.5, 4.6

-

Smoking status (Non-smoker)

0.0

(−0.3, 0.3)

0.793

-

-

-

4.2

4.1, 4.3

-

Alcohol consumption ≥30 g/day (No)

−1.5

(−2.5, −0.4)

0.008

-

-

-

4.2

4.1, 4.3

P < 0.01

Rheumatoid arthritis (No)

−2.2

(−2.7, −1.6)

<0.001

−2.1

(−2.6, −1.6)

<0.001

6.4

5.8, 4.2

P < 0.01

Family antecedents of osteoporosis (No)

−0.2

(−0.4, 0.1)

0.132

-

-

-

4.0

3.9, 4.7

-

Use of corticosteroids (No)

−2.3

(−3.9, −0.8)

0.002

−2.2

(−3.7, −0.6)

0.007

4.2

4.1, 4.3

P < 0.01

  1. Notes: aModel build for each factor adjusted by BMD and prior osteoporotic BF; bModel calculated with all the factors at the same time; NS = Not significant. The global mean (95% CI) for the undiscounted DALYs multivariate model was 14.6 (12.2; 17.1) and 10.0 (8.3; 11.6) for the discounted DALYs. *For categorical variables the reference category is given between brackets.