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Table 1 Demographic, serologic, and clinical characteristics of individuals with repeat dengue virus infections

From: Sequential dengue virus infections detected in active and passive surveillance programs in Thailand, 1994–2010

  All data (n = 502 individuals)a Cohort extended dataset (n = 205)
Gender   
Female 252 100
Male 237 95
Unknown 13 10
Age   
At infection one (mean years ± SD) 7.6 ± 3.0 9.0 ± 1.7
At infection two (mean years ± SD) 11.2 ± 3.0 11.2 ± 2.0
Serologic response at infection one b   
Primary 84 6
Secondary 263 59
Unknown (symptomatic) 15 -
Unknown (Subclinical/nonhospitalized) 56 56
Unknown (Subclinical) 84 84
Clinical category at infection one c   
Symp. (DHF) 201 24
Symp. (DHF/hospitalized DF) 16 3
Symp. (hospitalized DF) 123 16
Symp. (non-hospitalized DF) 19 19
Symp. (hospitalized/non-hospitalized DF) 3 3
Subclinical/non-hospitalized 56 56
Subclinical 84 84
Clinical category at infection two c   
Symp. (DHF) 201 17
Symp. (DHF/hospitalized DF) 13 -
Symp. (hospitalized DF) 112 16
Symp. (non-hospitalized DF) 33 29
Symp. (hospitalized/non-hospitalized DF) 1 1
Subclinical/non-hospitalized 42 42
Subclinical 100 100
  1. a488 individuals had two detected infections; 14 had three detected infections.
  2. bThe serologic response could not be categorized in 155 individuals; 140 could not be categorized because they were either subclinical (n = 84) or had seroconversion outside the active surveillance period in cohort studies (n = 56); 15 were symptomatic but had inadequate samples to determine serologic response.
  3. cSubclinical infections in cohort studies were identified by ≥ four-fold rise in dengue hemagglutination inhibition (HAI) titers without detection of symptomatic infection during the intervening surveillance period. Infections captured outside the active study surveillance period by HAI without a recognized hospitalization were marked as ‘subclinical/non-hospitalized’. Hospitalized cases that did not have sufficient clinical information for clinical categorization were marked ‘DHF/hospitalized DF.’ Four infections categorized as DF but with uncertain hospitalization status were marked as ‘hospitalized/non-hospitalized DF’.