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Table 6 Projected outcomes over 20 years with progressive addition of interventions that improve general TB services plus MDR diagnosis and treatment in Kazakhstan (per 1000 persons from general population)

From: Modeling the impact of tuberculosis interventions on epidemiologic outcomes and health system costs

Category of intervention

Scenario

Primary active cases arising in cohort over 20 years1

Total projected outcomes related to the primary active cases

 

Death during diagnosis and treatment phase

Cure due to treatment

Secondary cases generated from primary cases

Health system costs

 

Baseline

15 · 28

10 · 05

0 · 62

22 · 99

$5,238 · 87

General Health System Interventions

Improved diagnosis to detect 100% of TB cases in public sector (DS and MDR)

15 · 28

7 · 67

1 · 57

17 · 07

$12,292 · 55

Above & improved treatment to achieve 100% cure for DS in public sector

15 · 28

4 · 96

8 · 60

12 · 22

$12,354 · 14

Above & reduced loss to follow up in public sector

15 · 28

2 · 70

11 · 53

7 · 23

$16,351 · 62

MDR-TB related interventions

Above & Improve DST coverage to 100%

15 · 28

2 · 59

11 · 72

6 · 96

$18,441 · 46

Above & Improved treatment coverage so that all MDR cases diagnosed get standard MDR therapy

15 · 28

2 · 07

12 · 61

5 · 66

$27,327 · 96

Above & New MDR drugs so treatment outcomes are as good as drug sensitive TB cases

15 · 28

1 · 85

13 · 11

5 · 41

$28,513 · 34

  1. 1Primary cases are those which would arise from reactivation of pre-existing latent TB infection, or progression from newly acquired infection, but do NOT include cases arising from transmission from the primary cases.