From: Modeling the impact of tuberculosis interventions on epidemiologic outcomes and health system costs
Intervention | Specific parameter changed1 | Primary active cases arising in cohort over 20 years3 | Total projected outcomes related to the primary cases | |||||
---|---|---|---|---|---|---|---|---|
 | Parameter | Pre-intervention | Post-intervention | Death during diagnosis/treatment phase | Cure due to treatment | Secondary cases generated from primary cases | Health system costs | |
Baseline | - | - | - | 19 · 27 | 12 · 52 | 0 · 97 | 28 · 87 | $2,641 · 47 |
Community Education | Patient delay2 | 11% | 6% | 19 · 27 | 12 · 39 | 0 · 99 | 28 · 54 | $2,696 · 70 |
DOTS expansion for diagnosis | Incorrect Diagnostic Test (in public sector) | 60% | 35% | 19 · 27 | 11 · 90 | 1 · 24 | 27 · 38 | $3,302 · 55 |
Diagnostic Delay2 (in public sector) | 8% | 0 · 5% | 19 · 27 | 12 · 48 | 0 · 98 | 28 · 71 | $2,670 · 63 | |
Loss to follow up during Diagnosis (in public sector) | 25% | 14% | 19 · 27 | 12 · 37 | 1 · 03 | 28 · 51 | $2,800 · 83 | |
DOTS Expansion for Treatment | Incorrect Treatment (in public sector) | 79% | 13% | 19 · 27 | 12 · 02 | 2 · 33 | 27 · 89 | $2,646 · 61 |
Non specific DOTS Expansion (NTP Strengthening) | Access Government Facility | 43% | 73% | 19 · 27 | 12 · 42 | 0 · 99 | 28 · 62 | $2,764 · 86 |
Private Sector interventions | Incorrect Diagnostic test (in private sector) | 62% | 36% | 19 · 27 | 11 · 75 | 1 · 33 | 27 · 04 | $3,455 · 53 |
Diagnostic Delay2 (in private sector) | 11% | 0 · 7% | 19 · 27 | 12 · 46 | 0 · 98 | 28 · 63 | $2,685 · 49 | |
Loss to follow up during Diagnosis (in private sector) | 25% | 14% | 19 · 27 | 12 · 35 | 1 · 05 | 28 · 46 | $2,823 · 16 | |
Incorrect Treatment (in private sector) | 77% | 13% | 19 · 27 | 11 · 97 | 2 · 48 | 27 · 79 | $2,647 · 19 | |
HIV/ ART therapy programmes | HIV (+) Death | 12% | 10% | 19 · 27 | 12 · 52 | 0 · 97 | 28 · 87 | $2,641 · 47 |
HIV (+) Relapse | 16% | 1% | 19 · 27 | 12 · 52 | 0 · 97 | 28 · 87 | $2,641 · 47 | |
HIV (+) Reactivation | 3 · 4% | 2% | 19 · 26 | 12 · 52 | 0 · 96 | 28 · 86 | $2,640 · 66 | |
MDR-TB related interventions | DST performed | 20% | 50% | 19 · 27 | 12 · 52 | 0 · 97 | 28 · 87 | $2,693 · 77 |
Loss to follow up during MDR Treatment | 22% | 11% | 19 · 27 | 12 · 52 | 0 · 97 | 28 · 87 | $2,642 · 53 |