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Table 4 Logistic regression results for the association between smoking more than 20 cigarettes per day and selected polymorphisms

From: Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey

SNP/Genotype FTND No. of subjects OR(95% CI)p-value CPD* No. of subjects OR (95% CI) p-value HSI No. of subjects OR (95% CI)p-value TTF No. of subjects OR (95% CI) p-value
<4 ≥4 ≤20 >20 <3 ≥3 ≤5 min >5 min
rs16969968 at CHRNA5/             
GG 218 252 1 397 44 1 251 219 1 103 367 1
AA + AG 222 277 1.08 (0.83-1.40) 0.56 391 70 1.63 (1.09-2.45) 0.017** 251 248 1.13 (0.88-1.46) 0.33 127 372 1.22 (0.91-1.65) 0.19
rs578776 at CHRNA3/             
CC 232 269 1 403 62 1 264 237 1 119 382 1
TT + TC 208 260 1.09 (0.84-1.41) 0.52 385 52 0.89 (0.60-1.30) 0.56 238 230 1.08 (0.84-1.39) 0.55 111 357 0.99 (0.73-1.33) 0.94
rs12914008 at CHRNB4/             
GG 398 485 1 717 105 1 455 428 1 209 674 1
AA + AG 42 44 0.86 (0.55-1.35) 0.52 71 9 0.87 (0.42-1.80) `0.70 47 39 0.88 (0.57-1.38) `0.58 21 65 1.04 (0.61-1.77) 0.90
  1. *Only daily smokers.
  2. **A rounded down p-value. The exact p-value is 0.01756.
  3. The values in boldface denote the suggestive association when applying Bonferroni correction procedure for multiple testing (significance level: p = 0.017).
  4. ORs are adjusted for age, sex and remaining polymorphisms.