Figure 2

Graph of the potential for CD4 count recovery (i.e., intercept) versus the CD4 gain per virion eliminated (i.e., the magnitude of the slope). Notice that the patients split into four categories: (a) patients with a high slope magnitude and high intercept, (b) patients with a high slope magnitude and low intercept, (c) patients with a low slope magnitude and high intercept, and (d) patients with a low slope magnitude and low intercept. The red dots represent patients that did not reach viral suppression after one year of therapy. The continuous green line marks the AIDS threshold. The dotted green curve marks the set of parameters for which individuals reach viral suppression (i.e., V _e = 400 HIV RNA copies/ml) and low R₀ (i.e., R₀ = 1.1) simultaneously. Patients with parameters in the region to the right of the dotted curve would first reach a low R₀ and then viral suppression while the converse holds to the left of the dotted curve. For very potent regimens, both viral suppression and low R₀ are achieved by patients with parameters throughout this space.