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Table 4 Mean (SD) values of secondary outcomes: comparison of sustained beneficial change* and no sustained beneficial change groups in each study year.

From: Prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention RCT in Newcastle upon Tyne, UK

Outcome Time   Sustained beneficial change   No sustained beneficial change Difference p-value
   n Mean (SD) n Mean (SD) Mean (95% CI)  
Weight (Kg)        
  Year 0 47 91.4 (12.8) 55 92.6 (15.6) -1.2 (-6.9, 4.5) 0.68
  Year 1 47 88.4 (14.7) 35 93.0 (13.8) -4.6 (-10.8, 1.6) 0.15
  Year 2 47 87.0 (13.7) 25 93.5 (17.0) -6.5 (-13.8, 0.9) 0.08
  Year 3 43 86.7 (13.4) 17 87.4 (9.2) -0.7 (-7.8, 6.4) 0.84
  Year 4 43 87.9 (13.7) 13 88.0 (10.1) -0.1 (-8.3, 8.2) 0.99
  Year 5 32 88.4 (14.2) 10 85.1 (11.7) 3.3 (-6.8, 13.3) 0.52
Activity(score/day)        
  Year 0 37 93.6 (8.3) 49 103.1 (16.7) -9.5 (-15.4,-3.5) 0.002
  Year 1 33 101.0 (12.8) 26 100.9 (14.0) 0.1 (-6.9, 7.07) 0.99
  Year 2 31 102.5 (12.4) 18 96.6 (14.1) 6.0 (-1.8, 13.8) 0.13
  Year 3 33 106.4 (17.0) 18 100.6 (11.2) 5.8 (-3.1, 14.7) 0.20
  Year 4 34 105.3 (11.6) 13 97.9 (12.6) 7.5 (-0.3, 15.2) 0.06
  Year 5 22 103.7 (15.5) 10 103.2 (11.5) 0.4 (-10.8, 11.7) 0.94
Fibre (g/day)        
  Year 0 30 17.6 (6.1) 54 20.5 (6.5) -2.9 (-5.8, -0.0) 0.050
  Year 1 29 22.4 (10.2) 37 16.2 (6.3) 6.2 (2.2, 10.3) 0.003
  Year 2 27 24.4 (10.0) 32 17.8 (6.8) 6.6 (2.2, 11.0) 0.004
  Year 3 27 21.2 (8.1) 26 15.7 (5.3) 5.5 (1.7, 9.3) 0.005
  Year 4 24 21.5 (7.9) 22 16.7 (7.4) 4.7 (0.2, 9.3) 0.043
  Year 5 20 20.6 (8.2) 13 15.1 (4.9) 5.4 (0.3, 10.6) 0.039
Fat (% energy)        
  Year 0 42 37 (07) 51 31 (09) 6.2 (2.6, 9.7) 0.001
  Year 1 39 31 (10) 27 34 (06) -2.2 (6.5, 2.1) 0.306
  Year 2 37 31 (06) 22 35 (06) -4.4 (7.8, -1.0) 0.011
  Year 3 41 29 (07) 12 36 (07) -6.2 (-1.1, -1.7) 0.007
  Year 4 36 29 (06) 10 35 (06) -5.2 (-9.5, -0.9) 0.02
  Year 5 24 30 (07) 9 38 (05) -8.3 (-13.5, -3.1) 0.003
Carbohydrate (% energy)        
  Year 0 31 44(07) 52 49(08) -4.5(-8.1,1.0) 0.013
  Year 1 28 48(11) 38 48(10) -0.3(-5.4,4.6) 0.89
  Year 2 26 50(07) 33 46(10) 3.3(-1.2, 7.9) 0.15
  Year 3 31 52(08) 22 44(11) 8.4(3.1, 13.7) 0.002
  Year 4 28 51(10) 18 47(08) 3.5(-2.1, 9.1) 0.22
  Year 5 21 48(09) 12 47(07) 1.0(-5.2, 7.2) 0.74
  1. * Sustained beneficial change in secondary outcome measures was defined as: a beneficial change (>0.01 units) maintained for two or more years (i.e. weight loss, reduction in % energy intake from fat, increase in % intake from carbohydrate, increase in intake of dietary fibre and increase in physical activity score).