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Table 1 Categorisation of drugs and herbs by main ingredients

From: Drugs and herbs given to prevent hepatotoxicity of tuberculosis therapy: systematic review of ingredients and evaluation studies

Type

Name

Description of ingredients

Number of studies

Country

Herbal preparations

Yue hua wan

Various combinations of more than 11 Chinese herbs decocted in water

1

China [10]

 

Bu pi yang fei bao gan decoction

11 herbs decocted in water

1

China [12]

 

Phytotherapy

Infusions of a combination of herbs (on average 25) tailored to individual patients

1

Russia [13]

Finished manufactured herbal products

Hu gan pian

Tablet including a combination of six ingredients (herbs, animal extract, green bean)

8

China [14–21]

 

Silymarin

Extract of milk thistle

11

China [22–32]

 

Astragalus

Plant extract given intravenously

1

China [33]

 

Astragalus dasyanthus

Tincture containing: coumarins; ferrocoumarins; tanning substances; sugars; saponins; ascorbic acid; flavonoids; phytosterols; tocopherols

1

Russia [34]

 

Biphenyldicarboxylate

Tablet with extract of wu wei zi plant

2

China [35, 36]

 

Biphenyldicarboxylate

Extract of wu wei zi combined with glucurolactone

1

China [37]

 

Wu zhi capsule

Capsules with extract of the fruit of the wu wei zi plant

3

China [38–40]

 

San shen bao gan capsule

Capsules containing combination of 13 herbs

1

China [41]

 

Hugan yi fei granule

Granule containing a combination of 12 herbs

1

China [42]

 

Oleanolic acid

Tablet with extract of Swertia herb

5

China [43–47]

 

Hugan yao

Exact of Swertia herb combined with inosine and Vit C

1

China [48]

 

Dan shen

Injectable preparation of Chinese sage (Salvia Miltiorrhiza Bunge)

3

China [49–51]

 

Stimuliv

Tablets containing a combination of: Andrographis Paniculata; Eclipta alba; Peumas Boldus Molina; Cynara scolymus; Fumaria perviflora

1

India [52]

 

Galstena

Chelidonium majus; Taraxacum officinale; Carduus crispus (curled thistle extracted with enthanol)

1

Russia [53]

 

Optiliv

Capsules containing extracts of: Andrographis paniculata; Picrorhiza kurroa; Eclipta alba; Boerhaavia diffusia; Azadirachta indica; Swetia chirata; Solanum nigrum; Terminalia arjuna; Aphanamixis rohituka; Terminalia chebula; Furmaria indica; Excipients

1

India [11]

 

Glycyrrhizin

Capsules or injection containing extract of liquorice (gan cao)

6

China [54–59]

 

Anisodamine

Tablet containing plant extract

1

China [60]

 

Spirin or Spirulina

Derived from blue-green algae, contains proteins, vitamins and essential amino acids

2

China [61, 62]

   

1

Ukraine [63]

Combinations of vitamins and other non-herbal substances

Tiopronin (liu pu luo ning or kai xi lai)

Ramification of Glycine (amino acid)

17

China [64–80]

 

Glutathione (GSH) (tai te or a tuo mo lan)

Injectable antioxidant

5

China [81–85]

 

ATP

Adenosine Triphosphate

1

China [86]

 

Inosine

Inosine combined with vitamin C

1

China [87]

 

Essentiale

Vitamin B6, vitamin B12, derivatives of vitamin B3 (nicotinamide), vitamin E and essential phospholipids

1

China [88]

 

Gan ning pian

Liver hydrolysate, compounds of vitamin B, inositol, vitamin B6 and vitamin B12

1

China [89]

 

Tocopherol acetate

Vitamin E

1

Ukraine [90]

Pharmaceutical preparations

Glucurolactone

Manufactured drug

3

China [91–93]

 

Zixoryn

Manufactured drug

1

Russia [94]