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Table 2 Cox regression analysis for models exploring the relationship between exposure to the occupation and CVD in later life (B).

From: Cardiovascular disease in a cohort exposed to the 1940–45 Channel Islands occupation

  Covariate
(referent category)
Hazard
Ratio
95%
confidence
intervals
p value
Unadjusted Exposure to occupation (unexposed) 2.88 1.78 – 4.66 0.01
Unstratified, adjusted for potential confounders 1 Exposure to occupation (unexposed) 2.52 1.54 – 4.13 0.01
  Preterm gestational age (term) 0.28 0.04 – 2.05 0.21
  Birth weight (per kg increase) 1.15 0.73 – 1.83 0.55
  Manual paternal occupation (non-manual) 1.41 0.87 – 2.29 0.16
  Rural parish of birth (urban) 1.61 0.97 – 2.69 0.07
Stratified by parish, and adjusted for potential confounders 1 Exposure to occupation in urban parishes (unexposed) 2.75 1.41 – 5.35 0.012
  Exposure to occupation in rural parishes (unexposed) 2.28 1.08 – 4.81  
  1. 1 Gestational age at birth, birth weight, paternal occupation at birth and parish of residence at birth were all considered potential confounders. It is important to note that the interpretation of the estimated hazard ratios for potential confounders is not straightforward since the main exposure variable (exposure to the occupation) lies on the pathway between these potential confounders and the outcome variable (CVD in later life).
  2. 2 p value for interaction between birth weight and sex.