From: Cost-effectiveness of tuberculosis evaluation and treatment of newly-arrived immigrants
Parameter varied | Value | Active cases | Add TB4s | Overall (all) | ||||
---|---|---|---|---|---|---|---|---|
 | Base | New | QALYs | Cost | QALYs | Cost | QALYs | Cost |
None | - | - | 4.1 (0.3) | -17 (1.6) | 2.9 (0.1) | -10 (0.7) | 7.7 (0.3) | -25 (1.5) |
Passive treatment delay (days) | 74 | 100 | 5.8 (0.2) | -14 (1.4) | 3.7 (0.2) | -12 (1) | 10 (0.3) | -22 (1.7) |
Screening delay (days) | 0 | 14 | 4.4 (0.3) | -17 (1.4) | 3.2 (0.2) | -11 (1.1) | 8.1 (0.2) | -25 (1.7) |
Fraction of active cases | 3% | 6% | 8.1 (0.3) | -290 (2.2) | 3.1 (0.2) | -11 (0.7) | 12 (0.4) | -290 (2.5) |
Baseline smear-positive rate | 7.5% | 15% | 5.2 (0.3) | -9.6 (0.9) | 3.3 (0.3) | -11 (0.8) | 9.3 (0.4) | -18 (0.9) |
Transmission rate (Note 1) | 8 | 16 | 4.2 (0.3) | -22 (1.6) | 3.4 (0.2) | -12 (1) | 8.3 (0.3) | -33 (1.6) |
Hospitalization rates | Â | Â | Â | Â | Â | Â | Â | Â |
   Actively detect, smear pos. | 0.35 | 0.66 | 4.1 (0.2) | 0.8 (1) | 3.6 (0.2) | -11 (1) | 8.3 (0.3) | -7.2 (1.6) |
   Passively detect, smear pos. | 0.66 | 0.33 | 3.8 (0.13) | +8.3 (1.7) | 3.4 (0.2) | -1.0 (0.7) | +7.9 (0.3) | +12 (2.3) |
   Actively detect, smear neg. | 0.081 | 0.162 | 4.1 (0.2) | +27 (0.7) | 3 (0.18) | -8.6 (0.6) | 7.7 (0.3) | +22 (1.2) |
   Passively detect, smear neg. | 0.51 | 0.255 | 3.5 (0.3) | +140 (0.6) | 3.2 (0.15) | 1.5 (0.8) | 7.3 (0.3) | +150 (1) |
Reactivation rates, Note 2 | Â | Â | Â | Â | Â | Â | Â | Â |
   TB4s | 600 | 430 | 4 (0.3) | -16 (1.3) | 2.5 (0.15) | 1.0 (0.7) | 7.1 (0.3) | -12 (2) |
Cost multipliers | Â | Â | Â | Â | Â | Â | Â | Â |
   Hospitalization costs | same | +20% | 4.1 (0.3) | -67 (1.5) | 3 (0.13) | -16 (0.9) | 7.8 (0.3) | -83 (1.5) |
   Costs, excluding hospital | same | +20% | 3.4 (0.18) | +14 (0.9) | 3.5 (0.2) | -4.6 (1.1) | 7.7 (0.3) | +14 (1.6) |
Selected costs | Â | Â | Â | Â | Â | Â | Â | Â |
   Nurse refill visit | 16.80 | 8.40 | 3.7 (0.2) | -17 (1.1) | 3.3 (0.13) | -26 (0.8) | 7.5 (0.3) | -43 (1.4) |
   DOT visit | 19.23 | 25.00 | 4.5 (0.2) | -16 (1.2) | 3.0 (0.2) | -11 (1) | 7.8 (0.4) | -24 (1.8) |
TST specificity | 0.99 | 0.875 | 4.1 (0.2) | -14 (1.1) | 3.0 (0.2) | -11 (0.9) | 7.6 (0.3) | -21 (1.2) |
Fraction INH resistant | 0.13 | 0.2 | 3.9 (0.3) | -14 (1) | 2.3 (0.2) | -5.3 (0.8) | 6.7 (0.4) | -16 (0.9) |
Risk multiplier, severe hepatitis | 1 | 3 | 3.9 (0.3) | -16 (0.9) | 3.0 (0.15) | -5.4 (0.5) | 7.6 (0.3) | -17 (1) |
Selected disutilities | Â | Â | Â | Â | Â | Â | Â | Â |
   Hepatitis hospitalization | 0.4 | 0.9 | 4.3 (0.3) | -15 (1.5) | 3.1 (0.2) | -10 (0.9) | 8.0 (0.3) | -23 (1.6) |
   Outpatient hepatitis | 0.265 | 0.5 | 4.3 (0.2) | -16 (1.3) | 3.1 (0.17) | -9.9 (1.1) | 8.0 (0.3) | -24 (2) |
   Other INH side-effects | 0.1 | 0.2 | 3.9 (0.2) | -15 (1) | 2.9 (0.13) | -10 (0.7) | 7.4 (0.2) | -22 (1.2) |
   Untreated TB | 0.1 | 0.2 | 4.8 (0.19) | -15 (1) | 3.6 (0.15) | -10 (0.9) | 9.0 (0.3) | -22 (1.5) |
Lost QALYs, INH one month | 0 | 0.01 | 4.5 (0.3) | -15 (1.1) | -15 (0.2) | -9.9 (0.8) | -16 (0.4) | -22 (0.9) |
Disutility multipliers | Â | Â | Â | Â | Â | Â | Â | Â |
   TB hospitalization | 1 | 0.5 | 4.0 (0.19) | -16 (1.4) | 3.3 (0.1) | -10 (1) | 7.9 (0.2) | -24 (1.3) |
   Outpatient TB | 1 | 0.5 | 4.2 (0.3) | -16 (1.3) | 3.4 (0.2) | -8 (0.7) | 8.3 (0.3) | -21 (1.6) |
Discount rate per year | 0.03 | 0.05 | 3.2 (0.15) | -13 (1) | 2.4 (0.13) | -6.9 (1.2) | 5.9 (0.2) | -16 (1.6) |
TST sensitivity | 0.93 | 0.95 | 4.2 (0.2) | -17 (1.3) | 3.4 (0.15) | -11 (1) | 8.3 (0.3) | -25 (1.7) |
TST specificity | 0.99 | 0.95 | Â | Â | Â | Â | Â | Â |