Table 2 Base case scenario parameters. Selected parameters for cost-effectiveness of California tuberculosis B-notifications. Full details and additional parameters are given in the Appendix [see Additional file 1]. Note 1: California TB surveillance for individuals from major countries of origin, 2002. Note 2: one minus the relative risk of disease given completion of LTBI therapy relative to no therapy, assuming isoniazid-sensitive infection. Note 3: assuming no false positives due to prior BCG vaccination. Note 4: rate per 100 000 person-years. See Appendix [Additional file 1] for further details and complete references.
From: Cost-effectiveness of tuberculosis evaluation and treatment of newly-arrived immigrants
Description | Values |
|---|---|
Mean age (Note 1) | 53.3 |
INH resistance | 0.129 |
Drug-induced hepatitis rates | 0.0008 to 0.0028 |
Efficacy of completed regimen (Note 2) | 70% |
Mean time to passive diagnosis | 74 days |
TST sensitivity | 93% |
TST specificity (Note 3) | 99% |
Probability of fast progression to TB after infection | 0.05 |
Probability of finding a TB contact | 80% |
Fraction of individuals with B-notification | Â |
   with active disease | 3% |
   in class TB4 | 60% |
   in class TB2 | 22% |
Fraction of | Â |
   baseline active cases smear positive | 7.5% |
   TB4s eligible for LTBI therapy | 63% |
Hospitalization probability | Â |
   actively detected smear-positive | 0.35 |
   actively detected smear-negative | 0.081 |
   passively detected smear-positive | 0.66 |
   passively detected smear-negative | 0.51 |
Transmission (new infections per year) | Â |
   smear-positive source case | 8 |
   smear-negative source case | 0.8 |
Attrition cascade for domestic follow-up after B-notification | Â |
   Evaluation rate | 60% |
   Starting rate, LTBI therapy | 80% |
   Completion rate, LTBI therapy | 75% |
Reactivation rate at baseline, Note 4 | Â |
   class TB4 | 600 |
   class TB2 | 217 |