From: High prevalence of thalassemia in migrant populations in Guangdong Province, China
Individuals only with α-thalassemia | Individuals only with β-thalassemia | Individuals combined α-/β- thalassemia carriers | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Genotypes | Frequency | Prevalence (%95 CI) | Genotypes (clinic forms) | Frequency | Prevalence (%95 CI) | Genotypes (clinic forms) | Frequency | Prevalence (%95 CI) | Genotypes (clinic forms) | Frequency | Prevalence (%95 CI) |
α+-thalassemia | 1626 | 5.71% (5.44, 5.98) | β-thalassemia minor | 1077 | 3.78 (3.56, 4.00) | --SEA/αα, β41–42/βN (α0, β0/βN) | 34 | 0.12 (0.08,0.16) | --SEA/α3.7, β41–42/βN (HbH, β0/βN) | 1 | 0.00 (0.00,0.01) |
α3.7α/αα | 911 | 3.20 (3.00, 3.40) | β41–42/βN (β0/βN) | 415 | 1.46 (1.32, 1.60) | --SEA/αα, β654/βN (α0, β0/βN) | 25 | 0.09 (0.05,0.12) | --SEA/αα, β-28/βIVS-1 (α0, β+/β0) | 1 | 0.00 (0.00,0.01) |
α4.2α/αα | 313 | 1.10 (0.98, 1.22) | β654/βN (β0/βN) | 281 | 0.99 (0.87, 1.10) | α3.7/αα, β41–42/βN (α+, β0/βN) | 20 | 0.07 (0.04,0.10) | --SEA/αα, β-29/βN (α0, β+/βN) | 1 | 0.00 (0.00,0.01) |
αWSα/αα | 239 | 0.84 (0.73, 0.94) | β17/βN (β0/βN) | 95 | 0.33 (0.27, 0.40) | α3.7/αα, β-28/βN (α+, β+/βN) | 11 | 0.04 (0.02,0.06) | --SEA/αα, βIVS-5/βN (α0, β+/βN) | 1 | 0.00 (0.00,0.01) |
αCSα/αα | 83 | 0.29 (0.23, 0.35) | β71–72/βN (β0/βN) | 24 | 0.08 (0.05, 0.12) | --SEA/αα, β-28/βN (α0, β+/βN) | 9 | 0.03 (0.01,0.05) | α3.7/αCSα, β41–42/βN (α0, β0/βN) | 1 | 0.00 (0.00,0.01) |
αQSα/αα | 47 | 0.17 (0.12, 0.21) | β27–28/βN (β0/βN) | 19 | 0.07 (0.04, 0.10) | α3.7/αα, β654/βN (α+, β0/βN) | 8 | 0.03 (0.01,0.05) | α3.7/αα, β-29/βN (α+, β+/βN) | 1 | 0.00 (0.00,0.01) |
α3.7α/α4.2α | 9 | 0.03 (0.01, 0.05) | β14–15/βN (β0/βN) | 10 | 0.04 (0.01, 0.06) | αWSα/αα, β41–42/βN (α+, β0/βN) | 7 | 0.02 (0.01,0.04) | α3.7/αα, βIVS-1/βN (α+, β0/βN) | 1 | 0.00 (0.00,0.01) |
α3.7α/α3.7α | 8 | 0.03 (0.01, 0.05) | β43/βN (β0/βN) | 6 | 0.02 (0.00, 0.04) | α4.2/αα, β41–42/βN (α+, β0/βN) | 6 | 0.02 (0.00,0.04) | αCSα/αα, β17/βN (α+, β0/βN) | 2 | 0.01 (0.00,0.02) |
α3.7α/αWSα | 5 | 0.02 (0.00, 0.03) | βIVS-1/βN (β0/βN) | 6 | 0.02 (0.00, 0.04) | --SEA/αα, β17/βN (α0, β0/βN) | 4 | 0.01 (0.00,0.03) | αCSα/αα, β654/βN (α+, β0/βN) | 2 | 0.01 (0.00,0.02) |
α3.7α/αCSα | 3 | 0.01 (0.00, 0.02) | βInt/βN (β0/βN) | 1 | 0.00 (0.00, 0.01) | --SEA/αα, βE/βN (α0, β+/βN) | 4 | 0.01 (0.00,0.03) | α3.7/αα, βIVS-5/βN (α+, β+/βN) | 1 | 0.00 (0.00,0.01) |
α3.7α/αQSα | 3 | 0.01 (0.00, 0.02) | β-28/βN (β+/βN) | 155 | 0.54 (0.46, 0.63) | α3.7/αα, β17/βN (α+, β0/βN) | 4 | 0.01 (0.00,0.03) | α4.2/αα, β71–72/βN (α+, β0/βN) | 1 | 0.00 (0.00,0.01) |
α4.2α/αWSα | 3 | 0.01 (0.00, 0.02) | βE/ βN (β+/βN) | 24 | 0.08 (0.05, 0.12) | α4.2/αα, β-28/βN (α+, β+/βN) | 4 | 0.01 (0.00,0.03) | α4.2/αα, βCap/βN (α+, β+/βN) | 1 | 0.00 (0.00,0.01) |
α4.2α/αCSα | 1 | 0.00 (0.00, 0.01) | βCap/βN (β+/βN) | 23 | 0.08 (0.05, 0.11) | αCSα/αα, β41–42/βN (α+, β0/βN) | 4 | 0.01 (0.00,0.03) | αCSα/αα, β-28/βN (α+, β+/βN) | 1 | 0.00 (0.00,0.01) |
α4.2α/αQSα | 1 | 0.00 (0.00, 0.01) | β-29/βN (β+/βN) | 17 | 0.06 (0.03, 0.09) | α3.7/αα, β71–72/βN (α+, β0/βN) | 3 | 0.01 (0.00,0.02) | αWSα/αα, β71–72/βN (α+, β0/βN) | 1 | 0.00 (0.00,0.01) |
α0-thalassemia | 1743 | 6.12 (5.84, 6.40) | βIVS-5/βN (β+/βN) | 1 | 0.00 (0.00, 0.01) | α4.2/αα, β17/βN (α+, β0/βN) | 3 | 0.01 (0.00,0.02) | αWSα/αα, βE/βN (α+, β+/βN) | 1 | 0.00 (0.00,0.01) |
--SEA/αα | 1743 | 6.12 (5.84, 6.40) | β-thalassemia intermedia | 4 | 0.01 (0.00, 0.03) | α4.2/αα, β654/βN (α+, β0/βN) | 3 | 0.01 (0.00,0.02) | αWSα/αα, βIVS-1/βN (α+, β0/βN) | 1 | 0.00 (0.00,0.01) |
HbH disease | 58 | 0.20 (0.15, 0.26) | β-28/βE (β+/β+) | 1 | 0.00 (0.00, 0.01) | --SEA/α3.7, β654/βN (HbH, β0/βN) | 2 | 0.01 (0.00,0.02) | |||
--SEA/α3.7 | 33 | 0.12 (0.08, 0.16) | β41–42/βCap (β0/β+) | 1 | 0.00 (0.00, 0.01) | --SEA/αCSα, β41–42/βN (HbH, β0/βN) | 2 | 0.01 (0.00,0.02) | |||
--SEA/α4.2 | 15 | 0.05 (0.03, 0.08) | β41–42/βE (β0/β+) | 1 | 0.00 (0.00, 0.01) | --SEA/αα, β71–72/βN (α0, β0/βN) | 2 | 0.01 (0.00,0.02) | |||
--SEA/αWSα | 5 | 0.02 (0.00, 0.03) | β-28/β17 (β+/β0) | 1 | 0.00 (0.00, 0.01) | α4.2/αα, βE/βN (α+, β+/βN) | 2 | 0.01 (0.00,0.02) | |||
--SEA/αCSα | 3 | 0.01 (0.00, 0.02) | αWSα/αα, β654/βN (α+, β0/βN) | 2 | 0.01 (0.00,0.02) | ||||||
--SEA/αQSα | 2 | 0.01 (0.00, 0.02) | --SEA/α3.7, β17/βN (HbH, β0/βN) | 1 | 0.00 (0.00,0.01) | ||||||
Total | 3427 | 12.03 (11.66, 12.41) | Total | 1081 | 3.80 (3.57,4.02) | Total | 178 | 0.63 (0.53,0.72) |