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Table 3 Association between household cigarettes, birth weight, and wheezing status in adolescents

From: Low birth weight and environmental tobacco smoke increases the risk of wheezing in adolescents: a retrospective cohort study

Adjusted OR*

Household cigarettes (per day)

(95% CI)

0

1–20

21–40

≥41

Ever Wheezing

    

Birth weight (g)

    

 <2500

1.08 (1.01–1.16)

1.03 (0.97–1.10)

1.24 (1.03–1.49)

1.73 (1.28–2.33)

 2500–3999

1.00 (Reference)

0.98 (0.97–1.00)

1.21 (1.17–1.26)

1.36 (1.27–1.45)

 ≥4000

0.98 (0.93–1.03)

0.92 (0.88–0.97)

1.17 (1.02–1.34)

1.17 (0.91–1.50)

Subgroup: excluded ever physician-diagnosed asthma cases

Birth weight (g)

    

 <2500

1.06 (0.97–1.17)

1.12 (1.03–1.22)

1.42 (1.14–1.78)

2.11 (1.49–2.98)

 2500–3999

1.00 (Reference)

1.05 (1.03–1.08)

1.38 (1.31–1.44)

1.60 (1.48–1.73)

 ≥4000

0.98 (0.92–1.05)

0.99 (0.94–1.06)

1.29 (1.09–1.52)

1.43 (1.07–1.90)

Subgroup: excluded ever physician-diagnosed rhinitis cases

Birth weight (g)

    

 <2500

1.05 (0.95–1.17)

1.10 (1.00–1.20)

1.48 (1.17–1.88)

2.12 (1.44–3.12)

 2500–3999

1.00 (Reference)

1.07 (1.04–1.09)

1.43 (1.36–1.51)

1.56 (1.43–1.70)

 ≥4000

0.97 (0.91–1.05)

1.01 (0.94–1.07)

1.24 (1.03–1.49)

1.24 (0.90–1.72)

Subgroup: excluded ever physician-diagnosed asthma or rhinitis cases

Birth weight (g)

    

 <2500

1.02 (0.89–1.16)

1.15 (1.03–1.28)

1.56 (1.18–2.06)

2.20 (1.41–3.44)

 2500–3999

1.00 (Reference)

1.10 (1.07–1.14)

1.54 (1.45–1.63)

1.72 (1.57–1.90)

 ≥4000

1.00 (0.92–1.09)

1.07 (0.99–1.15)

1.27 (1.03–1.58)

1.42 (0.99–2.03)

Current Wheezing

    

Birth weight (g)

    

 <2500

1.09 (1.00–1.20)

1.08 (1.00–1.18)

1.47 (1.18–1.84)

2.20 (1.56–3.09)

 2500–3999

1.00 (Reference)

1.05 (1.03–1.07)

1.33 (1.27–1.40)

1.66 (1.37–1.79)

 ≥4000

0.98 (0.92–1.04)

0.99 (0.93–1.05)

1.47 (1.25–1.72)

1.45 (1.09–1.93)

Subgroup: excluded ever physician-diagnosed asthma cases

Birth weight (g)

    

 <2500

1.07 (0.94–1.22)

1.16 (1.04–1.30)

1.94 (1.49–2.52)

2.57 (1.69–3.89)

 2500–3999

1.00 (Reference)

1.14 (1.10–1.17)

1.52 (1.43–1.61)

1.97 (1.80–2.16)

 ≥4000

1.00 (0.92–1.09)

1.08 (1.00–1.16)

1.62 (1.33–1.97)

2.00 (1.45–2.77)

Subgroup: excluded ever physician-diagnosed rhinitis cases

 Birth weight (g)

    

 <2500

1.06 (0.92–1.22)

1.16 (1.03–1.30)

1.82 (1.36–2.43)

2.91 (1.88–4.50)

 2500–3999

1.00 (Reference)

1.15 (1.11–1.19)

1.62 (1.52–1.72)

1.99 (1.80–2.20)

 ≥4000

1.01 (0.92–1.11)

1.06 (0.97–1.15)

1.51 (1.21–1.89)

1.50 (1.02–2.23)

Subgroup: excluded ever physician-diagnosed asthma or rhinitis cases

Birth weight (g)

    

 <2500

0.98 (0.81–1.18)

1.24 (1.07–1.43)

2.19 (1.57–3.04)

2.79 (1.63–4.78)

 2500–3999

1.00 (Reference)

1.21 (1.16–1.26)

1.74 (1.61–1.88)

2.22 (1.98–2.49)

 ≥4000

1.07 (0.95–1.20)

1.14 (1.03–1.26)

1.60 (1.23–2.07)

1.70 (1.09–2.66)

Wheezing with Exercise

    

Birth weight (g)

    

 <2500

1.11 (1.02–1.21)

1.33 (1.24–1.43)

1.66 (1.38–2.00)

2.86 (2.18–3.75)

 2500–3999

1.00 (Reference)

1.13 (1.11–1.16)

1.49 (1.43–1.55)

1.89 (1.78–2.01)

 ≥4000

1.06 (1.01–1.12)

1.13 (1.08–1.19)

1.46 (1.28–1.67)

1.81 (1.45–2.26)

Subgroup: excluded ever physician-diagnosed asthma cases

Birth weight (g)

    

 <2500

1.17 (1.01–1.23)

1.38 (1.28–1.49)

1.79 (1.45–2.20)

3.35 (2.51–4.47)

 2500–3999

1.00 (Reference)

1.18 (1.16–1.21)

1.58 (1.51–1.65)

2.06 (1.93–2.21)

 ≥4000

1.08 (1.02–1.15)

1.21 (1.14–1.27)

1.48 (1.27–1.73)

2.01 (1.58–2.56)

Subgroup: excluded ever physician-diagnosed rhinitis cases

Birth weight (g)

    

 <2500

1.11 (0.99–1.23)

1.32 (1.21–1.43)

1.84 (1.48–2.30)

2.74 (1.94–3.87)

 2500–3999

1.00 (Reference)

1.18 (1.15–1.21)

1.59 (1.52–1.67)

2.02 (1.87–2.17)

 ≥4000

1.07 (0.99–1.14)

1.20 (1.13–1.27)

1.41 (1.19–1.67)

1.92 (1.48–2.50)

Subgroup: excluded ever physician-diagnosed asthma or rhinitis cases

Birth weight (g)

    

 <2500

1.10 (0.98–1.24)

1.33 (1.21–1.43)

1.90 (1.50–2.40)

2.87 (1.99–4.13)

 2500–3999

1.00 (Reference)

1.20 (1.17–1.21)

1.60 (1.53–1.69)

2.10 (1.94–2.27)

 ≥4000

1.09 (1.02–1.18)

1.23 (1.15–1.27)

1.42 (1.18–1.70)

1.97 (1.49–2.60)

  1. *Adjusted for sex, age, parental education, gestation age, birth order.