Table 3 Genetic association analyses for paternal occupation: odds ratios, 95% confidence intervals and p-values for the genetic association analyses for paternal occupation (by groups; ‘managers and professionals’ as reference) using SNPs (additive genetic model), sex and age in a logistic regression model (CHR, chromosome)
Unskilled employees/workers | Qualified employees/workers | Technicians/associate pros. | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHR | Gene | SNP | Physical position | Supposed risk allele | OR | (95% CI) | p | OR | (95% CI) | p | OR | (95% CI) | p |
3 | PPARG | rs1801282 | 12393125 | C | 1.00 | (0.77–1.30) | 1.00 | 0.95 | (0.77–1.17) | 0.62 | 0.96 | (0.76–1.22) | 0.75 |
3 | IGF2BP2 | rs4402960 | 185511687 | T | 1.04 | (0.86–1.26) | 0.67 | 1.02 | (0.87–1.18) | 0.85 | 0.99 | (0.83–1.18) | 0.95 |
6 | CDKAL1 | rs10946398 | 20661034 | C | 1.01 | (0.83–1.23) | 0.94 | 1.15 | (0.99–1.34) | 0.08 | 1.17 | (0.98–1.39) | 0.09 |
6 | CDKAL1 | rs7754840 | 20661250 | C | 0.99 | (0.82–1.21) | 0.94 | 1.13 | (0.97–1.32) | 0.12 | 1.16 | (0.97–1.39) | 0.10 |
6 | CDKAL1 | rs7756992 | 20679709 | G | 1.06 | (0.86–1.30) | 0.59 | 1.13 | (0.96–1.33) | 0.15 | 1.23 | (1.02–1.49) | 0.03 |
8 | SLC30A8 | rs13266634 | 118184783 | C | 1.07 | (0.88–1.31) | 0.47 | 1.09 | (0.94–1.26) | 0.27 | 1.21 | (1.01–1.46) | 0.04 |
9 | CDKN2A/2B | rs564398 | 22029547 | A | 0.95 | (0.79–1.15) | 0.63 | 0.94 | (0.81–1.09) | 0.39 | 0.94 | (0.79–1.11) | 0.46 |
9 | CDKN2A/2B | rs10811661 | 22134094 | T | 0.98 | (0.77–1.24) | 0.85 | 1.10 | (0.91–1.33) | 0.33 | 0.94 | (0.76–1.17) | 0.59 |
10 | HHEX | rs1111875 | 94462882 | G | 0.87 | (0.72–1.05) | 0.14 | 0.97 | (0.84–1.12) | 0.71 | 0.98 | (0.83–1.16) | 0.80 |
10 | TCF7L2 | rs7903146 | 114758349 | T | 0.89 | (0.73–1.09) | 0.26 | 0.92 | (0.78–1.07) | 0.28 | 1.01 | (0.84–1.20) | 0.95 |
16 | FTO | rs8050136 | 53816275 | A | 1.09 | (0.90–1.31) | 0.38 | 1.05 | (0.91–1.21) | 0.53 | 1.00 | (0.85–1.18) | 1.00 |