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Table 2 Subgroup analysis of risk ratios per 100 ug/day increase in dietary folate intake and per 5 nmol/L increase in serum folate levels for prostate cancer

From: Folate intake, serum folate levels, and prostate cancer risk: a meta-analysis of prospective studies

Cancer sites Group RR and 95% CI P value Heterogeneity (%) P value for heterogeneity
Dietary folate intake Country
Europe 1.00 (0.98-1.02) 0.920 0.0 0.692
Other 1.01 (0.99-1.03) 0.232 0.0 0.677
Effect estimate
RR 1.00 (0.98-1.02) 0.743 0.0 0.361
HR 1.01 (0.99-1.03) 0.421 0.0 0.682
Follow-up (year)
15 or greater 1.01 (0.99-1.03) 0.421 0.0 0.682
<15 1.00 (0.98-1.02) 0.743 0.0 0.361
Adjusted age
Yes 1.01 (0.99-1.02) 0.601 0.0 0.577
No 1.01 (0.98-1.03) 0.548 0.0 0.432
Adjusted BMI
Yes 1.01 (0.98-1.03) 0.548 0.0 0.432
No 1.01 (0.99-1.02) 0.601 0.0 0.577
Adjusted alcohol consumption
Yes 1.01 (0.98-1.03) 0.548 0.0 0.432
No 1.01 (0.99-1.02) 0.601 0.0 0.577
Serum folate levels Country
Europe 1.05 (1.00-1.11) 0.062 23.2 0.272
Other 1.03 (0.82-1.29) 0.798 - -
Effect estimate
RR 1.09 (0.99-1.20) 0.079 - -
OR 1.03 (0.99-1.07) 0.132 0.0 0.440
Follow-up (year)
15 or greater 1.02 (0.98-1.06) 0.323 - -
<15 1.09 (1.02-1.18) 0.015 0.0 0.769
Adjusted age
Yes 1.03 (0.82-1.29) 0.798 - -
No 1.05 (1.00-1.11) 0.062 23.2 0.272
Adjusted BMI
Yes 1.06 (0.99-1.14) 0.102 48.0 0.146
No 1.05 (0.91-1.21) 0.507 0.0 0.845
Adjusted smoking
Yes 1.06 (0.99-1.14) 0.102 48.0 0.146
No 1.05 (0.91-1.21) 0.507 0.0 0.845