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Table 1 Characteristics of included studies in the meta-analysis

From: The association between breastfeeding and childhood obesity: a meta-analysis

Reference

Origin

Study design

Age

Sample sizea

Definition of feeding patterns

Definition of obesity

Confounders

Armstrong 2002 [39]

Great Britain

IHC

39-42 months

32,200

Formula-fed, BF

BMI ≥ 95th

Gender, birth weight, SES

Bergmann 2003 [40]

Germany

PC

6 years

480

Bottle-fed, BF

BMI ≥ 97th

Overweight mother, SESc

Beyerlein

2008 [41]

Germany

CS

54-88 months

9,368

Never & ever BF

BMI ≥ 97th

Weight gain from birth to years of life, maternal BMI, parents’ graduatebc

Burke 2005 [42]

Australia

PC

1-8 years

1,672

Never, BF ≤ 4 mo, BF ≤ 8 mo, BF ≤ 12 mo, BF > 12 mo

BMI ≥ 95th

Birth weight, gestational age, ethnicity, sex, maternal BMI, first child, and maternal educationc

Gillman 2001 [43]

United States

CS

9-14 years

14,377

Mostly or only fed formula, mostly or only BF

BMI ≥ 95th

Age, sex, birth weight, birth order, Tanner stage, exercises, daily energy intake, mother’s BMI, and household income, dietary restraint, weight cycling, and weight concernsbc

Grummer-Strawn 2004 [44]

United States

IHC

4 years

12,587

Never, BF < 1 mo, BF ≤ 2.9 mo, BF ≤ 5.9 mo, BF ≤ 11.9 mo, BF ≥ 12 mo

BMI ≥ 95th

Gender, race/ethnicity, birth weight, and mother’s age, education, prepregnancy BMI, and weight gain during pregnancy c

Hawkins 2009 [45]

Great Britain

PC

3 years

13,172

Never, BF < 4 mo, BF ≥ 4 mo

IOTF

Birth weight, gender, ethnicity, introduction of solid foods, maternal SES, education, lone motherhood status, age at first live birth, number of children, household income, parental overweight, country, et al.bc

Hediger 2001 [46]

United States

CS

3-5 years

2,656

Never & ever EBF

BMI ≥ 95th

Birth weight, race/ethnicity, gender, age group, mother’s BMI, timing of introduction to solid foods

Jwa 2014 [47]

Japan

PC

1.5-8 years

41,572

Formula feeding, mixed feeding, EBF

IOTF

Birth weight, having elder sibling(s), maternal educational level, age and total house-hold income at 0.5 years old c

Koletzko 2009 [48]

Germany

CS

5-6 years

9,357

Never & ever BF

BMI ≥ 97th

Parental education, low birth weight, own bedroom, frequent consumption of butterc

Kwok 2010 [49]

Hong Kong

PC

7 years

7,026

Never, partially or EBF <3 mo, EBF ≥ 3 mo

IOTF

Sex, birth weight, gestational age, birth order, mother’s age at birth, birthplace, number of hospital admissions at 0–3 months, parental education, occupation, incomec

Li 2003 [50]

Great Britain

CS

4-18 years

2,631

Never, BF ≤ 1 mo, BF ≤ 3 mo, BF ≤ 6 mo, BF ≤ 9 mo, BF > 9 mo

BMI ≥ 95th

Sex, parent’s BMI, birth weight, and social classc

Liese 2001 [51]

Germany

CS

9-10 years

2,108

Formula-fed, BF

BMI > 90th

Age, gender, city, nationality, SES, number of siblingsc

McCrory 2012 [52]

Republic of Ireland

IHC

9 years

7,798

Never, BF ≤ 4 wk, BF ≤ 8 wk, BF ≤ 12 wk, BF ≤ 25 wk, BF ≥ 26 wk

IOTF

Dietary quality, exercise, maternal education, gestational age, nationality, weight status, household incomebc

Moschonis 2008 [53]

Greek

IHC

1-5 years

2,374

Exclusive formula-fed, mixed, EBF

BMI ≥ 95th

Parental education, weight status, maternal gestational diabetes mellitus, alcohol consumption patterns during pregnancy, age at birth, birth rankc

Moss 2014 [54]

United States

PC

2-4 years

14,150

Never & ever BF

BMI ≥ 95th

Maternal education, maternal age, maternal race, family poverty, children’s birth weight and gender

Novaes 2011 [55]

Brazilian

CS

6-10 years

764

Never & ever BF

BMI > 2SD

Gender, physical education classes, siblings, maternal nutritional state during pregnancybc

O’Challaghan 1997 [56]

Australia

PC

5 years

2,034

Formula fed, BF ≥ 6 mo, exclusiveness unclear

BMI ≥ 94th

Birth weight, gander, small for gestational age, feeding problems, sleeplessness, parental BMI, maternal education, household income

Scholtens 2008 [57]

Dutch

PC

8 years

2,043

Never, BF ≤ 16 wk, BF > 16 wk

IOTF

Maternal education, overweight, diet at 7 years of agebc

Scott 2012 [58]

Australia

IHC

9-16 years

2,066

Never, BF < 2 mo, BF < 4 mo, BF < 6 mo, BF ≥ 6 mo

IOTF

Age, gender, energy intake, physical activity, sleep duration, maternal age, education, ethnicityb

Toschke 2002 [59]

Czech Republic

CS

6-14 years

33,768

Never & ever BF

BMI ≥ 97th

Parental education and obesity, birth weight, sports outside school, number of siblingsbc

Twells 2010 [60]

Canada

CS

4 years

1,026

formula feeding ≥ 3 mo, mixed feeding ≥3 mo, EBF ≥ 3 mo

BMI ≥ 95th

Birth weight, gender, age, maternal education, whether the baby was preterm or full termc

Van Rossem 2010 [61]

United States

PC

3 years

884

Never, any BF <6 mo, partial BF ≥ 6 mo, EBF ≥ 6 mo

BMI ≥ 95th

Age, sex, maternal educational, race, BMI, pregnancy weight gain, birth weight, gestational agec

Von Kries 1999 [62]

Germany

CS

5-6 years

9,206

Never, EBF ≤ 2 mo, EBF ≤ 5 mo, EBF ≤ 12 mo, BF > 12 mo

BMI ≥ 97th

Parental education, low birth weight, own bedroom, consumption of butterc

Zhao 2013 [63]

China

PC

2-8.4 years

1,189

Formula feeding, mixed feeding, EBF

Boys’ BMI ≥96.3th Girls’ BMI ≥98th

Maternal weight and BMI before pregnancy, maternal weight increase and the level of blood glucose during pregnancy, gender, birth weight, father weight

  1. Abbreviation: IHC indicates historical cohort, PC Prospective cohort, CS Cross-sectional, BMI body mass index (calculated as weight in kilograms divided by height in meters squared), BF breastfeeding, EBF Exclusive breastfeeding, IOTF the International Obesity Task Force, SES socio-economic status.
  2. aThe number of participants included in the analysis with different feeding patterns at last follow-up.
  3. bAdjustment for amount of watching TV for children.
  4. cAdjustment for maternal smoking in pregnancy.