Association between physical and mental health-related quality of life and adverse outcomes; a retrospective cohort study of 5,272 Scottish adults

Table 3 Cox regression models of the association between quintiles of mental component summary score (MCS) of the SF-12 and adverse outcomes

	Model 1		Model 2		Model 3
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
All-cause death
MCS quintile
1 (worst)	1.61 (1.24, 2.10)	<0.001	1.33 (1.01, 1.75)	0.041	1.25 (0.95, 1.65)	0.117
2	1.04 (0.76, 1.41)	0.824	1.00 (0.73, 1.37)	0.991	1.00 (0.73, 1.37)	0.998
3	0.83 (0.59, 1.15)	0.259	0.92 (0.66, 1.28)	0.603	0.88 (0.63, 1.23)	0.463
4	0.66 (0.47, 0.91)	0.012	0.77 (0.56, 1.08)	0.128	0.76 (0.55, 1.06)	0.104
5 (best)	1.00	-	1.00	-	1.00	-
Cancer registration
MCS quintile
1 (worst)	0.81 (0.59, 1.10)	0.171	0.75 (0.55, 1.03)	0.077	0.75 (0.55, 1.03)	0.079
2	0.75 (0.55, 1.03)	0.077	0.75 (0.54, 1.03)	0.075	0.74 (0.54, 1.03)	0.071
3	0.70 (0.51, 0.97)	0.033	0.73 (0.52, 1.01)	0.055	0.72 (0.52, 1.01)	0.054
4	0.78 (0.58, 1.06)	0.111	0.83 (0.61, 1.12)	0.215	0.82 (0.61, 1.11)	0.206
5 (best)	1.00	-	1.00	-	1.00	-
Coronary heart disease hospitalisation/death
MCS quintile
1 (worst)	0.91 (0.56, 1.48)	0.715	0.84 (0.51, 1.37)	0.480	0.84 (0.51, 1.38)	0.499
2	0.60 (0.35, 1.05)	0.072	0.61 (0.35, 1.06)	0.077	0.61 (0.35, 1.06)	0.082
3	0.55 (0.31, 0.97)	0.039	0.59 (0.33, 1.05)	0.071	0.59 (0.33, 1.05)	0.073
4	0.75 (0.46, 1.22)	0.252	0.79 (0.48, 1.29)	0.352	0.80 (0.49, 1.30)	0.363
5 (best)	1.00	-	1.00	-	1.00	-

Higher quintile indicate better mental health status; MCS, mental component summary quintile (score): 1 (<47), 2 (47 to 52.9), 3 (53 to 55.9), 4 (56 to 58), 5 (>58); HR, hazard ratio; CI, Confidence interval; Model 1 adjusted for age; Model 2 adjusted for age, sex, SIMD, education level, smoking status, alcohol consumption, hypertension and diabetes; Model 3 adjusted for same covariates as Model 2 plus body mass index.

ISSN: 1471-2458