Skip to main content

Table 4 Quality assessment of studies on lactose-free liquid feeds versus lactose-containing mixed diets

From: Dietary management of childhood diarrhea in low- and middle-income countries: a systematic review

   QUALITY ASSESSMENT SUMMARY OF FINDINGS
Number of studies Diarrhea mode Design Limitations Consistency Generalizability to population of interest Overall quality of evidence Number of events in intervention group Number of events in control group Effect size (95% CI)
OUTCOME: DURATION OF DIARRHEA Standardized Mean Difference
1 Acute RCT Single study of high quality - Non-malnourished infants and young children (≤24m) with acute diarrhea in LMICs Low - - 0.75 [0.22, 1.28]
1 Persistent RCT Single study of moderate quality - Malnourished weaned infants and young children (≤36m) with persistent diarrhea in LMICs Low - - 0.28 [-0.35, 0.90]
OUTCOME: STOOL OUTPUT Standardized Mean Difference
1 Acute RCT Single study of high quality - Non-malnourished infants and young children (≤24m) with acute diarrhea in LMICs Low - - 0.62 [0.09, 1.14]
2 Persistent RCT Only two studies, both of moderate quality Heterogeneous (I2= 50%) Malnourished weaned infants and young children (≤36m) with persistent diarrhea in LMICs Low - - 0.22 [-0.33, 0.78]
OUTCOME: WEIGHT GAIN Standardized Mean Difference
1 Acute RCT Single study of high quality - Non-malnourished infants and young children (≤24m) with acute diarrhea in LMICs Low - - 0.21 [-0.31, 0.72]
2 Persistent RCT Only two studies, both of moderate quality Heterogeneous (I2= 94%) Malnourished weaned infants and young children (≤36m) with persistent diarrhea in LMICs Low - - -0.35 [-2.00, 1.31]
OUTCOME: TREATMENT FAILURE Risk Ratio
2 Acute RCT Only two studies, ranging from moderate to high quality Heterogeneous (I2= 60%) Non-malnourished infants and young children (≤24m) with acute diarrhea in LMICs Low 7 3 1.79 [0.15, 20.66]
2 Persistent RCT Only two studies, both of moderate quality Heterogeneous (I2= 72%) Malnourished weaned infants and young children (≤36m) with persistent diarrhea in LMICs Low 6 7 1.25 [0.07, 23.66]