Table 1 Study characteristics
From: Systematic review of probiotics for the treatment of community-acquired acute diarrhea in children
Study arms | ||||||
|---|---|---|---|---|---|---|
Intervention | Control | |||||
Author | n | Probiotic microorganism (dosage) | Duration & method of treatment | n | Placebo | |
Boudraa [12] | 56 | L. bulgaricus &S. thermophilus (2x108 CFU/g) | 180 mL/kg/day infant formula given after initial oral rehydration | 56 | Infant formula acidified with lactic acid to match yogurt pH | |
Canani [13] | 100 | Lactobacillus GG (6x109 CFU/dose) | 2/day for 5 days in 20 ml water | 92 | Not described | |
91 | S. boulardii (5x109 live organisms/dose) | 2/day for 5 days in 20 ml water | 92 | |||
100 | Bacillus clausii (109 CFU/dose) | 2/day for 5 days in 20 ml water | 92 | |||
97 | L. bulgaricus, L. acidophilus, S. thermophilus, B. bifidum (5x108- 109 CFU/dose) | 2/day for 5 days in 20 ml water | 92 | |||
91 | Enterococcus faecium (7.5x107 CFU/dose) | 2/day for 5 days in 20 ml water | 92 | |||
Cetina-Sauri [18] | 65 | S. boulardii (200 mg/dose) | Every 8 hours in 5ml of cold liquid | 65 | 200mg glucose in 5ml cold liquid | |
Costa-Ribeiro [14] | 61 | Lactobacillus GG (10x109 CFU/day) | 1/day w/oral electrolyte solution | 63 | Inulin | |
Lee [15] | 50 | Lyophilized L. acidophilus and B. infantis (3x109 CFU of each/day) | 1/day for 4 days | 50 | Not described | |
Misra [16] | 105 | Lactobacillus GG (1x109 CFU/dose) | 1/day for 10 days | 105 | Identical placebo (crystalline microcellulose) | |
Rafeey [19] | 40 | L. acidophilus (5x109 CFU/capsule) | 2 capsules/ day | 40 | Not described | |
Veereman-Wauters [17] | Diarrhea duration: 25; Stool frequency: 22 | Lactobacillus GG, L. acidophilus, L. casei, L. plantarum, B. infantis (3x109 CFU/capsule) | 3 capsules/ day for 9 days | 22 | Identical placebo (maltodextrine) |