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Table 4 Application of CHERG Rules for selection of point estimate for sepsis mortality for inclusion to LiST model [7]

From: The effect of umbilical cord cleansing with chlorhexidine on omphalitis and neonatal mortality in community settings in developing countries: a meta-analysis

Outcome measure Studies Total Events Effect size GRADE quality of pooled estimate Application of standard rules
Sepsis specific neonatal mortality (n=1) Not reported 31 % reduction, statistically non-significant
(RR=0.69, 95 % CI 0.40-1.18)
Low Effect size for sepsis specific mortality was not used for inclusion in LiST model as results were not statistically significant and overall quality grade was “low”
All cause neonatal mortality (n=3) 838 23% reduction, Statistically significant
(RR=0.77, 95 % CI 0.63 - 0.94)
Moderate →
Low
Effect size for all-cause mortality was used for inclusion to LiST model. This was based on rule 1 that says that if there is no evidence for cause specific mortality and there is evidence for all-cause mortality, use the effect size for all-cause and down grade quality grade by one.