Runtime in seconds as a function of population size (in millions of agents), in log-log scale. Runtime is based on simulation of one influenza season in each of the 50 states and the District of Columbia. The states marked are WY (pop. approx. 500 K), PA (pop. approx. 11.8 M) and CA (pop. approx. 33.6 M). Observed runtimes were approximately 32.4 seconds per million individuals over the entire range of population sizes tested. Runs were performed using 16 threads on a 12-core Mac Pro with 64 GB of RAM, running at 2.93 GHz.