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Table 8 Clinical laboratory tests

From: A single-blinded, single-centre, controlled study in healthy adult smokers to identify the effects of a reduced toxicant prototype cigarette on biomarkers of exposure and of biological effect versus commercial cigarettes

Haematology

Haemoglobin

Haematocrit

Total and differential leukocyte count (neutrophils, eosinophils, basophils, monocytes, lymphocytes)

Red-blood-cell count

Platelet count

Mean corpuscular volume

Mean corpuscular haemoglobin

Mean corpuscular haemoglobin concentration

Clinical chemistry

Blood urea nitrogen

Creatininea

Total bilirubin

Alkaline phosphatase

AST

ALT

Sodium

Potassium

Glucose (fasting)

Calcium

Chloride

Creatinine kinase

γ-glutamyl transpeptidase

Total protein

Uric acid

Urea

Urinalysis (by sticks as part of clinical laboratory investigation)

pH

Specific gravity

Protein

Glucose

Ketones

Bilirubin

Blood

Nitrite

Urobilinogen

Leukocytes

Additional tests

Alcohol breath testb

Urine cotinineb

HIV

Hepatitis surface antigen

Hepatitis C virus

Urine drug screeningb

Amphetamines

Barbiturates

Benzodiazepines

Cocaine

MDMA

Methamphetine

Morphine

Methadone

Tricyclic antidepressants

Tetrahydrocannabinol

Urine pregnancy testb

  1. All tests, except the additional tests, will also be performed during the smokers’ day 108–109 in-clinic evaluations and at the end of the study.
  2. aTo be repeated in each 24 h in-clinic evaluation for all participants.
  3. bTo be repeated at all in-clinic evaluation visits for smokers and non-smokers.