A single-blinded, single-centre, controlled study in healthy adult smokers to identify the effects of a reduced toxicant prototype cigarette on biomarkers of exposure and of biological effect versus commercial cigarettes

Table 8 Clinical laboratory tests

Haematology
●	Haemoglobin
●	Haematocrit
●	Total and differential leukocyte count (neutrophils, eosinophils, basophils, monocytes, lymphocytes)
●	Red-blood-cell count
●	Platelet count
●	Mean corpuscular volume
●	Mean corpuscular haemoglobin
●	Mean corpuscular haemoglobin concentration
Clinical chemistry
●	Blood urea nitrogen
●	Creatinine^a
●	Total bilirubin
●	Alkaline phosphatase
●	AST
●	ALT
●	Sodium
●	Potassium
●	Glucose (fasting)
●	Calcium
●	Chloride
●	Creatinine kinase
●	γ-glutamyl transpeptidase
●	Total protein
●	Uric acid
●	Urea
Urinalysis (by sticks as part of clinical laboratory investigation)
●	pH
●	Specific gravity
●	Protein
●	Glucose
●	Ketones
●	Bilirubin
●	Blood
●	Nitrite
●	Urobilinogen
●	Leukocytes
●	Additional tests
●	Alcohol breath test^b
●	Urine cotinine^b
●	HIV
●	Hepatitis surface antigen
●	Hepatitis C virus
●	Urine drug screening^b
	○ Amphetamines
	○ Barbiturates
	○ Benzodiazepines
	○ Cocaine
	○ MDMA
	○ Methamphetine
	○ Morphine
	○ Methadone
	○ Tricyclic antidepressants
	○ Tetrahydrocannabinol
●	Urine pregnancy test^b

All tests, except the additional tests, will also be performed during the smokers’ day 108–109 in-clinic evaluations and at the end of the study.
^aTo be repeated in each 24 h in-clinic evaluation for all participants.
^bTo be repeated at all in-clinic evaluation visits for smokers and non-smokers.

ISSN: 1471-2458