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Table 8 Clinical laboratory tests

From: A single-blinded, single-centre, controlled study in healthy adult smokers to identify the effects of a reduced toxicant prototype cigarette on biomarkers of exposure and of biological effect versus commercial cigarettes

Haematology
Haemoglobin
Haematocrit
Total and differential leukocyte count (neutrophils, eosinophils, basophils, monocytes, lymphocytes)
Red-blood-cell count
Platelet count
Mean corpuscular volume
Mean corpuscular haemoglobin
Mean corpuscular haemoglobin concentration
Clinical chemistry
Blood urea nitrogen
Creatininea
Total bilirubin
Alkaline phosphatase
AST
ALT
Sodium
Potassium
Glucose (fasting)
Calcium
Chloride
Creatinine kinase
γ-glutamyl transpeptidase
Total protein
Uric acid
Urea
Urinalysis (by sticks as part of clinical laboratory investigation)
pH
Specific gravity
Protein
Glucose
Ketones
Bilirubin
Blood
Nitrite
Urobilinogen
Leukocytes
Additional tests
Alcohol breath testb
Urine cotinineb
HIV
Hepatitis surface antigen
Hepatitis C virus
Urine drug screeningb
Amphetamines
Barbiturates
Benzodiazepines
Cocaine
MDMA
Methamphetine
Morphine
Methadone
Tricyclic antidepressants
Tetrahydrocannabinol
Urine pregnancy testb
  1. All tests, except the additional tests, will also be performed during the smokers’ day 108–109 in-clinic evaluations and at the end of the study.
  2. aTo be repeated in each 24 h in-clinic evaluation for all participants.
  3. bTo be repeated at all in-clinic evaluation visits for smokers and non-smokers.