Day and suggested times | Sampling | Procedure |
---|---|---|
1, 78, 162 | ||
1700 h (check in) | Blood, urine | Measure BP, PR, RR and temperature; abbreviated physical examination and medical history; illicit drug, alcohol and cotinine testing; pregnancy testing; dinner |
1900 h | None | Start first 24 h urine collection |
2100 h | None | Snack |
2, 79, 163 | ||
0700 h | Blood | Measure BP, PR, RR and temperature; measure creatinine in serum; biomarkers and gene expressiona |
0800 h | None | Breakfast |
1000 h | None | Administer quality of life and diet and lifestyle questionnairesb |
1200 h | None | Lunch |
1500 h | None | Measure exhaled CO |
1700 h | Saliva | Cotinine testing; dinner |
1900 h | None | End first and start second 24 h urine collection |
2100 h | None | Snack |
3, 80, 164 | ||
0700 h | Blood | Measure creatinine in serum; biomarkers |
0800 h | None | Breakfast |
1000 h | None | Administer quality of life and |
1100 h | None | Pulmonary-function test§ |
1200 h | None | Lunch |
1500 h | None | Measure exhaled CO |
1700 h | Saliva | Cotinine testing; dinner |
1900 h | None | End second 24 h urine collection |
164 (check out) | ||
Any time | Blood, urine | Measure BP, PR, RR and temperature; physical examination; electrocardiography; clinical laboratory tests |