Table 5 Hazard ratios and 95% confidence intervals (CI) for the association between calcium and risk of GI cancer, stratified by overweight (BMI</≥25 kg/m 2 ) in sub-cohort with baseline measurements of BMI
From: Serum calcium and risk of gastrointestinal cancer in the Swedish AMORIS study
Not Overweight (N = 24,511) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Oesophageal cancer | Stomach cancer | Colon cancer | Rectal cancer | Colorectal cancer | ||||||
n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | |
Calcium (SD: 0.10 mmol/L) | 2.02 (1.33-3.07) | 0.81 (0.57-1.14) | 1.01 (0.84-1.21) | 1.10 (0.88-1.38) | 1.04 (0.91-1.21) | |||||
Quartiles of calcium | ||||||||||
< 2.32 | 3 | 1.00 (Ref) | 13 | 1.00 (Ref) | 34 | 1.00 (Ref) | 18 | 1.00 (Ref) | 52 | 1.00 (Ref) |
2.32-2.38 | 3 | 1.04 (0.20-5.30) | 11 | 0.67 (0.28-1.51) | 42 | 1.08 (0.68-1.71) | 28 | 1.72 (0.72-2.38) | 70 | 1.05 (0.91-1.21) |
2.38-2.45 | 4 | 1.86 (0.39-8.87) | 7 | 0.53 (0.20-1.37) | 33 | 1.07 (0.65-1.75) | 30 | 1.74 (0.95-3.20 | 63 | 1.15 (0.87-1.52) |
≥ 2.45 | 7 | 3.28 (0.73-14.71) | 9 | 0.58 (0.23-1.47) | 32 | 0.91 (0.54-1.55) | 20 | 1.03 (0.52-2.04) | 52 | 0.57 (0.34-0.96) |
P-value for trend | 0.07 | 0.21 | 0.73 | 0.74 | 0.95 | |||||
Albumin-corrected calcium 1 | 1.93 (1.32-2.82) | 1.03 (0.61-1.14) | 1.02 (0.86-1.21) | 1.10 (0.90-1.35) | 1.05 (0.93-1.20) | |||||
(SD: 0.09 mmol/L) | ||||||||||
Quartiles of albumin-corrected calcium 1 | ||||||||||
< 2.27 | 2 | 1.00 (Ref) | 8 | 1.00 (Ref) | 23 | 1.00 (Ref) | 16 | 1.00 (Ref) | 39 | 1.00 (Ref) |
2.27-2.33 | 2 | 0.90 (0.13-6.84) | 10 | 1.08 (0.42-2.73) | 31 | 1.20 (0.70-2.05) | 19 | 1.03 (0.53-2.00) | 50 | 1.13 (0.74-1.71) |
2.33-2.39 | 3 | 1.06 (0.18-6.37) | 12 | 1.04 (0.42-2.55) | 42 | 1.30 (0.78-2.16) | 29 | 1.26 (0.68-2.33) | 71 | 1.28 (0.87-1.90) |
≥ 2.39 | 10 | 2.94 (0.64-13.65) | 10 | 0.71 (0.28-1.80) | 45 | 1.12 (0.67-1.86) | 32 | 1.14 (0.62-2.09) | 87 | 1.13 (0.76-1.66) |
P-value for trend | 0.07 | 0.42 | 0.72 | 0.58 | 0.53 | |||||
Overweight (N = 38,517) | ||||||||||
Calcium (SD: 0.10 mmol/L) | 0.69 (0.38-1.28) | 1.04 (0.74-1.46) | 0.97 (0.81-1.16) | 0.98 (0.77-1.25) | 0.97 (0.84-1.13) | |||||
Quartiles of calcium | ||||||||||
< 2.31 | 5 | 1.00 (Ref) | 11 | 1.00 (Ref) | 35 | 1.00 (Ref) | 18 | 1.00 (Ref) | 53 | 1.00 (Ref) |
2.31-2.37 | 3 | 0.61 (0.14-2.61) | 8 | 0.66 (0.26-1.65) | 35 | 0.85 (0.53-1.37) | 22 | 1.01 (0.54-1.90) | 57 | 0.91 (0.60-1.32) |
2.37-2.44 | 1 | 0.27 (0.03-2.36) | 11 | 1.08 (0.45-2.58) | 39 | 1.09 (0.68-1.75) | 16 | 0.82 (0.41-1.64) | 55 | 0.99 (0.67-1.47) |
≥ 2.44 | 3 | 1.00 (0.21-4.78) | 9 | 1.00 (0.38-2.60) | 28 | 0.83 (0.48-1.42) | 21 | 1.09 (0.55-2.17) | 49 | 0.92 (0.61-1.41) |
P-value for trend | 0.72 | 0.52 | 0.76 | 0.94 | 0.85 | |||||
Albumin-corrected calcium 1 | ||||||||||
(SD: 0.09 mmol/L) | 0.77 (0.44-1.35) | 1.06 (0.78-1.45) | 0.99 (0.84-1.17) | 0.99 (0.79-1.23) | 0.99 (0.86-1.13) | |||||
Quartiles of albumin-corrected calcium 1 | ||||||||||
< 2.27 | 3 | 1.00 (Ref) | 8 | 1.00 (Ref) | 24 | 1.00 (Ref) | 15 | 1.00 (Ref) | 39 | 1.00 (Ref) |
2.27-2.33 | 3 | 0.77 (0.15-3.82) | 7 | 0.65 (0.24-1.79) | 31 | 0.94 (0.55-1.60) | 15 | 0.72 (0.35-1.48) | 46 | 0.85 (0.56-1.31) |
2.33-2.39 | 3 | 0.73 (0.15-3.65) | 9 | 0.81 (0.31-2.10) | 43 | 1.26 (0.76-2.08) | 23 | 1.08 (0.56-2.08) | 66 | 1/13 (0.80-1.77) |
≥ 2.39 | 3 | 0.65 (0.13-3.29) | 15 | 1.15 (0.48-2.75) | 39 | 0.95 (0.57-1.59) | 24 | 0.92 (0.48-1.77) | 63 | 0.94 (0.63-1.41) |
P-value for trend | 0.62 | 0.52 | 0.90 | 0.84 | 0.83 | |||||