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Table 5 Hazard ratios and 95% confidence intervals (CI) for the association between calcium and risk of GI cancer, stratified by overweight (BMI</≥25 kg/m 2 ) in sub-cohort with baseline measurements of BMI

From: Serum calcium and risk of gastrointestinal cancer in the Swedish AMORIS study

Not Overweight (N = 24,511)       
  Oesophageal cancer Stomach cancer Colon cancer Rectal cancer Colorectal cancer
  n HR (95% CI) n HR (95% CI) n HR (95% CI) n HR (95% CI) n HR (95% CI)
Calcium (SD: 0.10 mmol/L) 2.02 (1.33-3.07)   0.81 (0.57-1.14)   1.01 (0.84-1.21)   1.10 (0.88-1.38)   1.04 (0.91-1.21)
Quartiles of calcium           
  < 2.32 3 1.00 (Ref) 13 1.00 (Ref) 34 1.00 (Ref) 18 1.00 (Ref) 52 1.00 (Ref)
  2.32-2.38 3 1.04 (0.20-5.30) 11 0.67 (0.28-1.51) 42 1.08 (0.68-1.71) 28 1.72 (0.72-2.38) 70 1.05 (0.91-1.21)
  2.38-2.45 4 1.86 (0.39-8.87) 7 0.53 (0.20-1.37) 33 1.07 (0.65-1.75) 30 1.74 (0.95-3.20 63 1.15 (0.87-1.52)
  ≥ 2.45 7 3.28 (0.73-14.71) 9 0.58 (0.23-1.47) 32 0.91 (0.54-1.55) 20 1.03 (0.52-2.04) 52 0.57 (0.34-0.96)
P-value for trend   0.07   0.21   0.73   0.74   0.95
Albumin-corrected calcium 1 1.93 (1.32-2.82)   1.03 (0.61-1.14)   1.02 (0.86-1.21)   1.10 (0.90-1.35)   1.05 (0.93-1.20)
  (SD: 0.09 mmol/L)           
Quartiles of albumin-corrected calcium 1         
  < 2.27 2 1.00 (Ref) 8 1.00 (Ref) 23 1.00 (Ref) 16 1.00 (Ref) 39 1.00 (Ref)
  2.27-2.33 2 0.90 (0.13-6.84) 10 1.08 (0.42-2.73) 31 1.20 (0.70-2.05) 19 1.03 (0.53-2.00) 50 1.13 (0.74-1.71)
  2.33-2.39 3 1.06 (0.18-6.37) 12 1.04 (0.42-2.55) 42 1.30 (0.78-2.16) 29 1.26 (0.68-2.33) 71 1.28 (0.87-1.90)
  ≥ 2.39 10 2.94 (0.64-13.65) 10 0.71 (0.28-1.80) 45 1.12 (0.67-1.86) 32 1.14 (0.62-2.09) 87 1.13 (0.76-1.66)
P-value for trend   0.07   0.42   0.72   0.58   0.53
Overweight (N = 38,517)          
Calcium (SD: 0.10 mmol/L) 0.69 (0.38-1.28)   1.04 (0.74-1.46)   0.97 (0.81-1.16)   0.98 (0.77-1.25)   0.97 (0.84-1.13)
Quartiles of calcium           
  < 2.31 5 1.00 (Ref) 11 1.00 (Ref) 35 1.00 (Ref) 18 1.00 (Ref) 53 1.00 (Ref)
  2.31-2.37 3 0.61 (0.14-2.61) 8 0.66 (0.26-1.65) 35 0.85 (0.53-1.37) 22 1.01 (0.54-1.90) 57 0.91 (0.60-1.32)
  2.37-2.44 1 0.27 (0.03-2.36) 11 1.08 (0.45-2.58) 39 1.09 (0.68-1.75) 16 0.82 (0.41-1.64) 55 0.99 (0.67-1.47)
  ≥ 2.44 3 1.00 (0.21-4.78) 9 1.00 (0.38-2.60) 28 0.83 (0.48-1.42) 21 1.09 (0.55-2.17) 49 0.92 (0.61-1.41)
P-value for trend   0.72   0.52   0.76   0.94   0.85
Albumin-corrected calcium 1          
  (SD: 0.09 mmol/L)   0.77 (0.44-1.35)   1.06 (0.78-1.45)   0.99 (0.84-1.17)   0.99 (0.79-1.23)   0.99 (0.86-1.13)
Quartiles of albumin-corrected calcium 1         
  < 2.27 3 1.00 (Ref) 8 1.00 (Ref) 24 1.00 (Ref) 15 1.00 (Ref) 39 1.00 (Ref)
  2.27-2.33 3 0.77 (0.15-3.82) 7 0.65 (0.24-1.79) 31 0.94 (0.55-1.60) 15 0.72 (0.35-1.48) 46 0.85 (0.56-1.31)
  2.33-2.39 3 0.73 (0.15-3.65) 9 0.81 (0.31-2.10) 43 1.26 (0.76-2.08) 23 1.08 (0.56-2.08) 66 1/13 (0.80-1.77)
  ≥ 2.39 3 0.65 (0.13-3.29) 15 1.15 (0.48-2.75) 39 0.95 (0.57-1.59) 24 0.92 (0.48-1.77) 63 0.94 (0.63-1.41)
P-value for trend   0.62   0.52   0.90   0.84   0.83
  1. All models are adjusted for age, sex, SES, albumin (continuous), and Charlson Comorbidity Index.
  2. 1 Not adjusted for albumin.