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Table 2 Impact of age at diagnosis and late presentation with HIV on mortality

From: Older HIV-infected individuals present late and have a higher mortality: Brighton, UK cohort study

N = 1965 Rate/1000 pyrs (95% CI) Univariable rate ratio (95% CI) p -value Multivariable rate ratio (95% CI) p -value
Age at HIV diagnosis (years)    <0.0001   <0.0001
<50 13.16(10.79-16.06) 1   1  
>50 35.65(24.92-50.98) 2.70(1.80-4.08)   2.88(1.88-4.40)  
CD4 count at diagnosis Cells/mm3    <0.0001   <0.0001
>350 7.59(5.16-11.14) 1   1  
<350 16.65(12.75-21.74) 2.19(1.37-3.50)   2.99(1.80-4.95)  
Unknown 30.53(22.94-40.63) 4.02(2.49-6.50)   6.60(3.86-11.28)  
Calendar period    <0.0001   <0.0001
1996-2001 42.61(31.81-57.06) 1   1  
2002-2005 12.91(9.13-18.26) 0.30(0.19-0.48)   0.37(0.23-0.58)  
2006-2010 10.69(8.10-14.11) 0.25(0.17-0.38)   0.31(0.21-0.47)  
Sex/HIV risk group    0.06   0.43
MSM 14.20(11.53-17.50) 1   1  
Female heterosexual 12.73(7.39-21.93) 0.90(0.50-1.61)   0.90(0.46-1.78)  
Male heterosexual 26.16(17.54-39.03) 1.84(1.17-2.89)   1.45(0.90-2.35)  
Others 26.16(6.54-104.60) 1.84(0.45-7.48)   1.26(0.31-5.14)  
Ethnicity    0.09   0.04
Caucasian 15.21(12.56-18.41) 1   1  
African/Caribbean 12.53(7.28-21.58) 0.82(0.46-1.47)   1.05(0.53-2.10)  
Others 33.55(17.46-64.49) 2.21(1.12-4.36)   2.78(1.37-5.62)  
ART status    0.01   <0.0001
Not on ART 20.81(15.81-27.38) 1   1  
On ART 13.20(10.54-16.52) 0.63(0.44-0.90)   0.33(0.22-0.50)