Health-related quality of life in adolescents with screening-detected celiac disease, before and one year after diagnosis and initiation of gluten-free diet, a prospective nested case-referent study

Table 3 Total adolescents, boys, and girls reporting problems in anxiety dimension (EQ-5D), before and 1 year after screening-detected celiac disease diagnosis, compared to referents without celiac disease

Groups at Baseline and Follow-up	Screening-detected CD (cases)	Non CD (referents)	Odds Ratios (95% CI)^a
	n (%) with problems	n (%) with problems	Bivariate LR^b	Multivariate LR^c
Total	n = 103	n = 483
Baseline	13 (12.6)	52 (10.8)	0.84 (0.44-1.60)	1.37 (0.70-2.69)
Follow-up	15 (14.6)	95 (19.7)	0.70 (0.39-1.26)	0.65 (0.35-1.20)
Boys	n = 47	n = 208
Baseline	4 (8.5)	16 (7.7)	1.12 (0.36-3.51)	1.46 (0.43-4.95)
Follow-up	2 (4.3)	18 (8.7)	0.47 (0.11-2.10)	0.41 (0.08-1.98)
Girls	n = 56	n = 275
Baseline	9 (16.1)	36 (13.1)	1.27 (0.57-2.81)	1.38 (0.61-3.13)
Follow-up	13 (23.2)	77 (28.0)	0.78 (0.40-1.53)	0.73 (0.37-1.47)

^a Odds ratio (95% confidence interval).
^b Bivariate logistic regression using case/referent and problems reported.
^c Multivariate logistic regression using case/referent and problems reported at baseline and problems reported at follow-up.

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