Relationship between prehypertension and chronic kidney disease in middle-aged people in Korea: the Korean genome and epidemiology study

Table 4 Unadjusted and multivariable-adjusted odds ratio (OR) for eGFR drop according to change in BP

BP change after 2 years	No. at risk	No. with eGFR drop (%)^a	eGFR drop
BP change after 2 years	No. at risk	No. with eGFR drop (%)^a	Unadjusted OR (95% CI)	Model 1 OR (95% CI)	Model 2 OR (95% CI)	Model 3 OR (95% CI)
All
Controlled BP ^b	3133	1644 (52.5)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Poorly-controlled BP ^c	2906	1827 (62.9)	1.53 (1.38-1.70)^**	1.31 (1.16-1.47)^**	1.23 (1.09-1.39)^**	1.22 (1.08-1.38)^*
c-statistic			0.55	0.74	0.75	0.76
Prehypertension
Controlled BP ^b	857	495 (57.8)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Poorly-controlled BP ^c	1510	997 (66.0)	1.42 (1.20-1.69)^**	1.39 (1.15-1.69)^**	1.35 (1.11-1.63)^*	1.37 (1.13-1.67)^*
c-statistic			0.54	0.74	0.75	0.76

^aeGFR drop denotes the decline in eGFR between baseline and the two-year follow-up.
(Changes in eGFR (Δ) = eGFR _{at two-year follow-up} – eGFR _{at baseline}).
^bControlled BP was defined as participants who had a normal BP at the two-year follow-up.
^cPoorly-controlled BP was defined as participants who were prehypertensive or hypertensive at the two-year follow-up.
Model 1: adjusted for age and sex.
Model 2: adjusted for age, sex and BMI.
Model 3: adjusted for age, sex, BMI, FBG, TC, TG, HDL-C, WC, current smokers and alcohol drinkers.
^* P<0.01, ^** P<0.001.

ISSN: 1471-2458