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Treatments
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CHD patients. Heart failure (HF) in the community is assumed to result in one third the fatality as HF in hospital and hypertension life expectancy is 80% that of US general population
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MediCare [4]
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May overestimate the life years lost due to deaths caused by HF in the community and hypertension.
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May overestimate the impact of treatments preventing and postponing deaths due to HF in the community and hypertension therefore making the estimated relative contribution of risk factors conservative.
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Risk Factors
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CHD patients. Median survival was assumed to be that of the post-AMI patients
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MediCare [4]
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May underestimate the benefit of reductions in risk factor prevalence
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Provides a conservative estimate
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Healthy population. survival was assumed to be that of general US population
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US Bureau of the Census [17]
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May both underestimate and overestimate the benefit or harms in terms of survival for each of the changes in risk factor prevalence
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Avoids methodological issues of non-additivity and double-counting
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Asymptomatic CHD. Survival was estimated as half-way between that of post-AMI patient and General US life expectancy
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MediCare and US Bureau of the Census [4, 17]
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Arbitrary and may underestimate the benefit of reductions in risk factor prevalence
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Provides a conservative estimate
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