Table 2 Univariate and multivariate Cox’s analyses of baseline EORTC QLQ-C30 for overall survival stratified by surgery status
From: Quality of life predicts survival in patients with non-small cell lung cancer
Variables | Surgery (N = 162) | Non-surgery (N = 312) | ||||||
|---|---|---|---|---|---|---|---|---|
N | # of death | Crude HR (95%C.I.) | Adjusted HR (95%C.I.) | N | # of death | Crude (95%C.I.) | Adjusted HR (95%C.I.) | |
QLQ-C30 | ||||||||
Physical Functioning (<100 as reference) | 81 | 25 | 1.00 | 1.00 | 225 | 130 | 1.00 | 1.00 |
=100 | 81 | 10 | 0.52 (0.25-1.09) | 0.61 (0.22-1.74) | 84 | 35 | 0.67 (0.46-0.98)* | 0.89 (0.59-1.35) |
Role Functioning (<100 as reference) | 27 | 5 | 1.00 | 1.00 | 105 | 61 | 1.00 | 1.00 |
=100 | 135 | 30 | 1.30 (0.51-3.36) | 2.73 (0.66-11.39) | 205 | 105 | 0.71 (0.52-0.98)* | 1.08 (0.75-1.54) |
Emotional Functioning (<83.33 as reference) | 62 | 12 | 1.00 | 1.00 | 122 | 63 | 1.00 | 1.00 |
83.33≤EFS < 100 | 44 | 11 | 1.29 (0.57-2.92) | 3.36 (1.05-10.69)* | 85 | 53 | 1.15 (0.8-1.66) | 1.20 (0.81-1.78) |
=100 | 56 | 12 | 1.06 (0.48-2.36) | 2.00 (0.67-5.96) | 105 | 52 | 0.96 (0.66-1.39) | 1.11 (0.75-1.66) |
Cognitive Functioning (<100 as reference) | 84 | 19 | 1.00 | 1.00 | 163 | 90 | 1.00 | 1.00 |
=100 | 78 | 16 | 0.82 (0.42-1.59) | 1.21 (0.53-2.76) | 149 | 78 | 1.00 (0.74-1.35) | 1.11 (0.79-1.56) |
Social Functioning (<100 as reference) | 65 | 16 | 1.00 | 1.00 | 159 | 94 | 1.00 | 1.00 |
=100 | 96 | 19 | 0.76 (0.39-1.48) | 1.41 (0.57-3.53) | 151 | 73 | 0.57 (0.42-0.78)*** | 0.70 (0.50-0.99)* |
Global QOL (≤50 as reference) | 54 | 16 | 1.00 | 1.00 | 166 | 98 | 1.00 | 1.00 |
50 < QLS≤66.67 | 55 | 7 | 0.43 (0.18-1.05) | 0.51 (0.17-1.53) | 72 | 40 | 0.75 (0.52-1.08) | 0.90 (0.61-1.32) |
>66.67 | 52 | 11 | 0.72 (0.33-1.55) | 0.98 (0.34-2.85) | 73 | 29 | 0.45 (0.29-0.68)*** | 0.79 (0.50-1.26) |
Fatigue (≤11.12 as reference) | 96 | 15 | 1.00 | 1.00 | 99 | 46 | 1.00 | 1.00 |
11.12 < FAS≤33.34 | 36 | 10 | 1.65 (0.74-3.67) | 1.78 (0.71-4.48) | 111 | 52 | 1.37 (0.92-2.04) | 1.49 (0.98-2.27) |
>33.34 | 30 | 10 | 1.83 (0.82-4.06) | 1.07 (0.37-3.09) | 102 | 70 | 2.52 (1.73-3.68)*** | 2.00 (1.34-3.00)*** |
Pain (=0 as reference) | 89 | 19 | 1.00 | 1.00 | 121 | 68 | 1.00 | 1.00 |
0 < Pain≤22.22 | 36 | 5 | 0.48 (0.18-1.28) | 0.20 (0.05-0.78)* | 73 | 34 | 0.73 (0.49-1.11) | 0.82 (0.53-1.29) |
>22.22 | 37 | 11 | 0.98 (0.47-2.07) | 0.53 (0.19-1.48) | 118 | 66 | 1.18 (0.84-1.66) | 1.02 (0.70-1.47) |
Nausea/Vomiting (=0 as reference) | 147 | 31 | 1.00 | 1.00 | 248 | 124 | 1.00 | 1.00 |
>0 | 15 | 4 | 0.79 (0.28-2.24) | 0.10 (0.02-0.56)** | 63 | 43 | 1.44 (1.02-2.04)* | 0.98 (0.66-1.44) |
Dyspnoea (=0 as reference) | 114 | 17 | 1.00 | 1.00 | 156 | 72 | 1.00 | 1.00 |
>0 | 48 | 18 | 1.80 (0.93-3.51) | 1.69 (0.70-4.07) | 155 | 96 | 1.49 (1.10-2.02)* | 1.08 (0.77-1.51) |
Insomnia (=0 as reference) | 93 | 18 | 1.00 | 1.00 | 154 | 80 | 1.00 | 1.00 |
>0 | 68 | 17 | 1.29 (0.67-2.51) | 1.62 (0.72-3.64) | 152 | 82 | 0.93 (0.69-1.27) | 0.99 (0.71-1.37) |
Appetite Loss (=0 as reference) | 125 | 28 | 1.00 | 1.00 | 188 | 84 | 1.00 | 1.00 |
>0 | 37 | 7 | 0.71 (0.31-1.63) | 0.39 (0.13-1.20) | 124 | 84 | 2.26 (1.66-3.07)*** | 1.79 (1.27-2.52)*** |
Constipation (=0 as reference) | 123 | 23 | 1.00 | 1.00 | 209 | 103 | 1.00 | 1.00 |
>0 | 39 | 12 | 1.86 (0.92-3.75) | 1.41 (0.51-3.92) | 102 | 65 | 1.38 (1.01-1.88)* | 1.12 (0.80-1.57) |
Diarrhoea (=0 as reference) | 147 | 31 | 1.00 | 1.00 | 263 | 136 | 1.00 | 1.00 |
>0 | 15 | 4 | 1.12 (0.40-3.18) | 0.49 (0.07-3.27) | 48 | 32 | 1.25 (0.85-1.84) | 1.28 (0.85-1.95) |
Financial Difficulties (=0 as reference) | 119 | 23 | 1.00 | 1.00 | 216 | 103 | 1.00 | 1.00 |
>0 | 41 | 11 | 1.52 (0.74-3.12) | 0.84 (0.28-2.55) | 94 | 64 | 1.83 (1.34-2.51)*** | 1.55 (1.08-2.20)* |