Table 1 Baseline characteristics of NSCLC patients stratified by surgery status and their relation to survival time
From: Quality of life predicts survival in patients with non-small cell lung cancer
Variables | Surgery (N = 162) | Non-surgery (N = 312) | ||||||
|---|---|---|---|---|---|---|---|---|
No. (%) | No. of deaths (%) | HR (95% C.I.) | P value | No. (%) | No. of deaths (%) | HR (95% C.I.) | P value | |
Gender | ||||||||
Male | 102 (62.96) | 26 (25.49) | 1.00 | 206 (66.03) | 118 (57.28) | 1.00 | ||
Female | 60 (37.04) | 9 (15.00) | 0.73 (0.34-1.55) | 0.41 | 106 (33.97) | 50 (47.17) | 0.63 (0.45-0.88) | 0.006 |
Age (yrs) | ||||||||
<50 | 32 (19.75) | 3 (9.38) | 1.00 | 48 (15.39) | 22 (45.38) | 1.00 | ||
50 ≤ Age < 60 | 32 (19.75) | 6 (18.75) | 1.42 (0.36-5.70 | 0.62 | 65 (20.83) | 34 (52.31) | 1.38 (0.81-2.36) | 0.24 |
60 ≤ Age < 70 | 45 (27.78) | 12 (26.67) | 2.01 (0.57-7.13) | 0.28 | 91 (29.17) | 47 (51.65) | 1.24 (0.75-2.05) | 0.41 |
70 ≤ Age < 80 | 50 (30.86) | 11 (22.00) | 1.90 (0.53-6.82) | 0.33 | 90 (28.85) | 52 (57.78) | 1.44 (0.87-2.37) | 0.15 |
≥80 | 3 (1.85) | 3 (100.00) | 8.38 (1.69-41.66) | 0.009 | 18 (5.77) | 13 (72.22) | 2.80 (1.41-5.57) | 0.003 |
Cancer Duration (yrs) | ||||||||
New cases | 102 (62.96) | 17 (16.67) | 1.42 (0.52-3.89) | 0.49 | 135 (43.27) | 66 (48.89) | 2.30 (1.43-3.70) | <0.001 |
Cancer duration <1 | 41 (25.31) | 13 (31.71) | 1.78 (0.63-5.00) | 0.27 | 124 (39.74) | 78 (62.90) | 2.36 (1.49-3.75) | <0.001 |
Cancer duration ≥1 | 19 (11.73) | 5 (26.32) | 1.00 | 53 (16.99) | 24 (45.28) | 1.00 | ||
Type of Cancer | ||||||||
Adenocarcinoma | 100 (61.73) | 19 (19.00) | 1.00 | 195 (62.50) | 98 (50.26) | 1.00 | ||
Squamous Cell | 51 (31.48) | 13 (25.49) | 1.17 (0.58-2.38) | 0.66 | 92 (29.49) | 55 (59.78) | 1.20 (0.86-1.67) | 0.28 |
Other | 11 (6.79) | 3 (27.27) | 3.57 (1.05-12.16) | 0.04 | 25 (8.01) | 15 (60.00) | 1.14 (0.66-1.96) | 0.65 |
Clinical Stage | ||||||||
IA, IB, IIA, IIB | 115 (70.99) | 18 (15.65) | 1.00 | 42 (13.46) | 12 (28.57) | 1.00 | ||
IIIA, IIIB | 39 (24.07) | 12 (30.77) | 2.36 (1.13-4.90) | 0.02 | 97 (31.09) | 54 (55.67) | 4.83 (2.57-9.08) | <0.001 |
IV | 8 (4.94) | 5 (62.50) | 7.44 (2.74-20.20) | <0.001 | 173 (55.45) | 102 (58.96) | 6.08 (3.30-11.21) | <0.001 |
Primary Tumora | ||||||||
T1 | 35 (21.74) | 5 (14.29) | 1.00 | 23 (7.54) | 12 (52.17) | 1.00 | ||
T2 | 88 (54.66) | 17 (19.32) | 1.44 (0.53-3.90) | 0.48 | 81 (26.56) | 32 (39.51) | 0.83 (0.43-1.61) | 0.58 |
T3 | 20 (12.42) | 7 (35.00) | 2.18 (0.69-6.88) | 0.18 | 28 (9.18) | 15 (53.57) | 1.30 (0.61-2.78) | 0.50 |
T4 | 18 (11.18) | 6 (33.33) | 3.21 (0.97-10.58) | 0.06 | 173 (56.72) | 105 (60.69) | 2.10 (1.15-3.83) | 0.02 |
Regional Lymph Nodesa | ||||||||
N0 | 104 (67.10) | 16 (15.38) | 1.00 | 67 (23.26) | 28 (41.79) | 1.00 | ||
N1 | 29 (18.71) | 8 (27.59) | 1.80(0.77-4.22) | 0.17 | 18 (6.25) | 7 (38.89) | 1.00 (0.44-2.30) | 0.99 |
N2 | 20 (12.90) | 6 (30.00) | 3.10(1.21-7.96) | 0.02 | 79 (27.43) | 45 (56.96) | 2.49 (1.54-4.02) | <0.001 |
N3 | 2 (1.29) | 1 (50.00) | 1.60(0.21-12.1) | 0.65 | 124 (43.06) | 80 (64.52) | 3.69 (2.36-5.76) | <0.001 |
Distant Metastasis | ||||||||
M0 | 152 (93.83) | 29 (19.08) | 1.00 | 139 (44.55) | 65 (46.76) | 1.00 | ||
M1 | 10 (6.17) | 6 (60.00) | 3.29 (1.36-7.93) | 0.008 | 173 (55.45) | 103 (59.54) | 2.12 (1.54-2.92) | <0.001 |
Type of Treatment | ||||||||
Pneumonectomy | ||||||||
No | 132 (90.41) | 24 (18.18) | 1.00 | |||||
Yes | 14 (9.59) | 1 (7.14) | 0.17 (0.02-1.29) | 0.09 | ||||
Lobectomy/Bilobectomy | ||||||||
No | 59 (40.41) | 14 (23.73) | 1.00 | |||||
Yes | 87 (59.59) | 11 (12.64) | 0.81 (0.37-1.79) | 0.60 | ||||
Wedge/Segmental resection | ||||||||
No | 98 (67.12) | 11 (11.22) | 1.00 | |||||
Yes | 48 (32.88) | 14 (29.17) | 2.23 (1.01-4.92) | 0.05 | ||||
Adjuvant Therapy | ||||||||
No | 61 (53.04) | 10 (16.39) | 1.00 | |||||
Yes | 54 (46.96) | 8 (14.81) | 1.32 (0.52-3.35) | 0.56 | ||||
Chemotherapeutic agentsa | ||||||||
Iressa | 25 (9.80) | 12 (48.00) | 1.00 | |||||
Navelbine | 129 (50.59) | 85 (65.89) | 1.69 (0.63-4.49) | 0.30 | ||||
Gemzar | 2 (0.78) | 2 (100.00) | 2.57 (1.12-5.88) | 0.03 | ||||
Taxol | 68 (26.67) | 37 (54.41) | 3.48 (0.7-17.29) | 0.13 | ||||
Taxotere | 20 (7.84) | 6 (30.00) | 2.45 (1.03-5.81) | 0.04 | ||||
Other | 11 (4.31) | 7 (63.64) | 3.88 (1.3-11.59) | 0.01 | ||||
Radiotherapy | ||||||||
No | 264 (87.42) | 138 (52.27) | 1.00 | |||||
Yes | 38 (12.58) | 22 (57.89) | 1.84 (1.16-2.90) | 0.009 | ||||