From: Genetic variability in IGF-1 and IGFBP-3 and body size in early life
Birthweight | Average somatotype | BMI at age 18 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
at ages 5 and 10 | |||||||||||
Gene | SNP | MAF | OR | 95% CI | p | OR | 95% CI | p | β | SE | p |
IGF-1 | rs1996656 | 0.18 | 0.96 | (0.80-1.15) | 0.64 | 1.03 | (0.93-1.14) | 0.57 | −0.0068 | 0.0050 | 0.17 |
rs4764695 | 0.50 | 1.06 | (0.97-1.16) | 0.16 | 1.01 | (0.93-1.10) | 0.75 | 0.0017 | 0.0044 | 0.70 | |
rs4764876 | 0.26 | 0.90 | (0.76-1.08) | 0.27 | 1.02 | (0.93-1.11) | 0.65 | 0.0045 | 0.0032 | 0.16 | |
rs2946834 | 0.32 | 0.93 | (0.85-1.02) | 0.12 | 1.00 | (0.92-1.08) | 0.91 | 0.0020 | 0.0029 | 0.49 | |
rs1520220 | 0.18 | 0.93 | (0.83-1.04) | 0.18 | 0.98 | (0.87-1.10) | 0.72 | −0.0037 | 0.0036 | 0.30 | |
rs1549593 | 0.13 | 1.02 | (0.89-1.16) | 0.79 | 0.95b | (0.72-1.26) | 0.73 | −0.0007 | 0.0063 | 0.91 | |
rs5742665 | 0.13 | 0.98 | (0.83-1.15) | 0.83 | 1.00 | (0.90-1.13) | 0.94 | 0.0103 | 0.0051 | 0.04 | |
rs2373722 | 0.07 | 0.91 | (0.77-1.08) | 0.28 | 0.88 | (0.71-1.08) | 0.21 | −0.0027 | 0.0053 | 0.61 | |
rs10735380 | 0.27 | 0.93 | (0.83-1.04) | 0.21 | 0.98 | (0.90-1.06) | 0.58 | −0.0031 | 0.0032 | 0.34 | |
rs2195239 | 0.23 | 0.94 | (0.83-1.08) | 0.39 | 1.01 | (0.92-1.10) | 0.85 | −0.0043b | 0.0080 | 0.59 | |
rs1019731 | 0.13 | 1.06 | (0.93-1.21) | 0.35 | 1.09 | (0.98-1.23) | 0.12 | 0.0021 | 0.0041 | 0.61 | |
rs12821878 | 0.22 | 1.11 | (0.99-1.23) | 0.06 | 1.09 | (0.94-1.28) | 0.26 | 0.0030 | 0.0034 | 0.38 | |
rs35767 | 0.16 | 0.98 | (0.87-1.12) | 0.81 | 0.89 | (0.77-1.04) | 0.14 | −0.0080 | 0.0038 | 0.03 | |
rs7965399 | 0.04 | 1.01 | (0.75-1.38) | 0.92 | 0.90 | (0.75-1.09) | 0.30 | −0.0026 | 0.0067 | 0.70 | |
IGFBP-1/IGFBP-3 | rs4619 | 0.35 | 1.02 | (0.91-1.14) | 0.75 | 0.99 | (0.84-1.17) | 0.93 | −0.0018 | 0.0029 | 0.54 |
rs2201638 | 0.03 | 0.92 | (0.57-1.48) | 0.73 | 1.05 | (0.71-1.56) | 0.80 | 0.0257 | 0.0156 | 0.10 | |
rs1065780 | 0.38 | 1.02 | (0.93-1.11) | 0.74 | 1.02 | (0.94-1.11) | 0.55 | −0.0002 | 0.0039 | 0.95 | |
rs1553009 | 0.20 | 1.04 | (0.94-1.17) | 0.44 | 1.10 | (1.00-1.21) | 0.06 | 0.0042 | 0.0035 | 0.23 | |
rs35539615 | 0.23 | 0.98 | (0.87-1.10) | 0.71 | 0.95 | (0.85-1.06) | 0.34 | 0.0018 | 0.0036 | 0.62 | |
rs1908751 | 0.30 | 0.97 | (0.88-1.07) | 0.56 | 0.95 | (0.87-1.03) | 0.20 | 0.0061 | 0.0031 | 0.05 | |
rs4988515 | 0.04 | 1.13 | (0.91-1.40) | 0.27 | 1.08 | (0.89-1.33) | 0.43 | −0.0018 | 0.0111 | 0.87 | |
rs10228265 | 0.31 | 0.94 | (0.86-1.03) | 0.19 | 0.98 | (0.90-1.06) | 0.59 | −0.0043 | 0.0030 | 0.15 | |
rs2270628 | 0.19 | 1.01 | (0.84-1.23) | 0.89 | 0.96 | (0.87-1.06) | 0.38 | −0.0052 | 0.0064 | 0.42 | |
rs6670 | 0.21 | 0.93 | (0.84-1.03) | 0.18 | 0.99 | (0.90-1.09) | 0.82 | 0.0033 | 0.0043 | 0.44 | |
rs2453839 | 0.20 | 0.97 | (0.86-1.08) | 0.54 | 1.02 | (0.84-1.25) | 0.84 | 0.0113b | 0.0086 | 0.19 | |
rs3110697 | 0.42 | 0.98 | (0.90-1.07) | 0.63 | 0.94 | (0.82-1.09) | 0.43 | −0.0055b | 0.0081 | 0.50 | |
rs2854746 | 0.40 | 1.09 | (1.00-1.20) | 0.06 | 1.02 | (0.94-1.10) | 0.65 | 0.0003 | 0.0029 | 0.91 | |
rs2854744 | 0.47 | 1.09 | (0.90-1.32) | 0.39 | 1.01 | (0.94-1.10) | 0.73 | −0.0029 | 0.0032 | 0.37 | |
rs2132570 | 0.22 | 0.96 | (0.81-1.15) | 0.69 | 0.92 | (0.83-1.03) | 0.16 | −0.0048 | 0.0049 | 0.33 | |
rs2960436 | 0.46 | 1.12 | (0.93-1.34) | 0.25 | 0.99 | (0.91-1.08) | 0.89 | −0.0023 | 0.0046 | 0.61 |