Skip to main content

Table 2 Associations between SNPs in IGF-1 and IGFBP-3 and body size in early life a

From: Genetic variability in IGF-1 and IGFBP-3 and body size in early life

    Birthweight Average somatotype BMI at age 18
   at ages 5 and 10  
Gene SNP MAF OR 95% CI p OR 95% CI p β SE p
IGF-1 rs1996656 0.18 0.96 (0.80-1.15) 0.64 1.03 (0.93-1.14) 0.57 −0.0068 0.0050 0.17
  rs4764695 0.50 1.06 (0.97-1.16) 0.16 1.01 (0.93-1.10) 0.75 0.0017 0.0044 0.70
  rs4764876 0.26 0.90 (0.76-1.08) 0.27 1.02 (0.93-1.11) 0.65 0.0045 0.0032 0.16
  rs2946834 0.32 0.93 (0.85-1.02) 0.12 1.00 (0.92-1.08) 0.91 0.0020 0.0029 0.49
  rs1520220 0.18 0.93 (0.83-1.04) 0.18 0.98 (0.87-1.10) 0.72 −0.0037 0.0036 0.30
  rs1549593 0.13 1.02 (0.89-1.16) 0.79 0.95b (0.72-1.26) 0.73 −0.0007 0.0063 0.91
  rs5742665 0.13 0.98 (0.83-1.15) 0.83 1.00 (0.90-1.13) 0.94 0.0103 0.0051 0.04
  rs2373722 0.07 0.91 (0.77-1.08) 0.28 0.88 (0.71-1.08) 0.21 −0.0027 0.0053 0.61
  rs10735380 0.27 0.93 (0.83-1.04) 0.21 0.98 (0.90-1.06) 0.58 −0.0031 0.0032 0.34
  rs2195239 0.23 0.94 (0.83-1.08) 0.39 1.01 (0.92-1.10) 0.85 −0.0043b 0.0080 0.59
  rs1019731 0.13 1.06 (0.93-1.21) 0.35 1.09 (0.98-1.23) 0.12 0.0021 0.0041 0.61
  rs12821878 0.22 1.11 (0.99-1.23) 0.06 1.09 (0.94-1.28) 0.26 0.0030 0.0034 0.38
  rs35767 0.16 0.98 (0.87-1.12) 0.81 0.89 (0.77-1.04) 0.14 −0.0080 0.0038 0.03
  rs7965399 0.04 1.01 (0.75-1.38) 0.92 0.90 (0.75-1.09) 0.30 −0.0026 0.0067 0.70
IGFBP-1/IGFBP-3 rs4619 0.35 1.02 (0.91-1.14) 0.75 0.99 (0.84-1.17) 0.93 −0.0018 0.0029 0.54
  rs2201638 0.03 0.92 (0.57-1.48) 0.73 1.05 (0.71-1.56) 0.80 0.0257 0.0156 0.10
  rs1065780 0.38 1.02 (0.93-1.11) 0.74 1.02 (0.94-1.11) 0.55 −0.0002 0.0039 0.95
  rs1553009 0.20 1.04 (0.94-1.17) 0.44 1.10 (1.00-1.21) 0.06 0.0042 0.0035 0.23
  rs35539615 0.23 0.98 (0.87-1.10) 0.71 0.95 (0.85-1.06) 0.34 0.0018 0.0036 0.62
  rs1908751 0.30 0.97 (0.88-1.07) 0.56 0.95 (0.87-1.03) 0.20 0.0061 0.0031 0.05
  rs4988515 0.04 1.13 (0.91-1.40) 0.27 1.08 (0.89-1.33) 0.43 −0.0018 0.0111 0.87
  rs10228265 0.31 0.94 (0.86-1.03) 0.19 0.98 (0.90-1.06) 0.59 −0.0043 0.0030 0.15
  rs2270628 0.19 1.01 (0.84-1.23) 0.89 0.96 (0.87-1.06) 0.38 −0.0052 0.0064 0.42
  rs6670 0.21 0.93 (0.84-1.03) 0.18 0.99 (0.90-1.09) 0.82 0.0033 0.0043 0.44
  rs2453839 0.20 0.97 (0.86-1.08) 0.54 1.02 (0.84-1.25) 0.84 0.0113b 0.0086 0.19
  rs3110697 0.42 0.98 (0.90-1.07) 0.63 0.94 (0.82-1.09) 0.43 −0.0055b 0.0081 0.50
  rs2854746 0.40 1.09 (1.00-1.20) 0.06 1.02 (0.94-1.10) 0.65 0.0003 0.0029 0.91
  rs2854744 0.47 1.09 (0.90-1.32) 0.39 1.01 (0.94-1.10) 0.73 −0.0029 0.0032 0.37
  rs2132570 0.22 0.96 (0.81-1.15) 0.69 0.92 (0.83-1.03) 0.16 −0.0048 0.0049 0.33
  rs2960436 0.46 1.12 (0.93-1.34) 0.25 0.99 (0.91-1.08) 0.89 −0.0023 0.0046 0.61
  1. aBirthweight was categorized as <5.5 lbs, 5.5-6.9 lbs, 7-8.4 lbs, 8.5-9.9 lbs, and 10+ lbs. Somatotypes at age 5 and 10 were categorized as 1,2,3,4,5+. BMI at age 18 was log-transformed and continuous. Birthweight and somatotypes at age 5 and 10 were analyzed in ordinal logistic regression models; BMI at age 18 was analyzed in a linear regression model. All models were adjusted for age at blood draw/cheek collection, menopausal status at blood draw/cheek collection and case selection, post-menopausal hormone use at blood draw/cheek collection and control selection, and DNA source (NHS only).
  2. bThe NHS and NHSII cohorts were combined using meta-analysis techniques. These estimates had P-het <0.05, indicating heterogeneity between the cohorts.
  3. Abbreviations: SNP: single nucleotide polymorphism; IGF-1: insulin-like growth factor 1; IGFBP-3: insulin-like growth factor binding protein 3; BMI: body mass index; MAF: minor allele frequency; OR: Odds Ratio; CI: confidence interval; SE: standard error.