Characteristics* | ACEI users (n = 64,710) | ARB users (n = 22,317) | Both drug users (n = 60,130) | ARB users vs. ACEI users§ Adjusted OR (95%CI) | Both drug users vs. ACEI users§ Adjusted OR (95%CI) | |||||
---|---|---|---|---|---|---|---|---|---|---|
Age † , mean (SD) | 54.7 | (17.1) | 57.8 | (14.0) | 59.7 | (12.8) | ||||
< 20 yrs | 2,657 | (4.1) | 71 | (0.3) | 102 | (0.2) | 0.13 | (0.10–0.17)# | 0.19 | (0.15–0.23)# |
20–39 yrs | 7,197 | (11.1) | 1,910 | (8.6) | 3,532 | (5.9) | 0.81 | (0.77–0.86)# | 0.60 | (0.57–0.63)¶ |
40–59 yrs | 28,172 | (43.5) | 10,534 | (47.2) | 24,565 | (40.9) | 0.99 | (0.96–1.02)# | 0.72 | (0.71–0.74)# |
> = 60 yrs (reference group) | 26,684 | (41.2) | 9,802 | (43.9) | 31,931 | (53.1) | 1 | 1 | ||
Sex | ||||||||||
Male | 33,267 | (51.4) | 11,984 | (53.7) | 29,810 | (49.6) | 1.08 | (1.04–1.11)# | 0.91 | (0.89–0.93)# |
Female (reference group) | 31,433 | (48.6) | 10,333 | (46.3) | 30,320 | (50.4) | 1 | 1 | ||
Clinical conditions ‡ | ||||||||||
Cardiovascular disease (CVD) risk (390–459) | 55,253 | (85.4) | 20,526 | (92.0) | 59,489 | (98.9) | 0.63 | (0.57–0.68)# | 6.14 | (5.54–6.81)# |
Diabetes (249–250) | 11,595 | (17.9) | 4,837 | (21.7) | 24,311 | (40.4) | 0.93 | (0.90–0.97)¶ | 2.04 | (1.98–2.10)# |
Kidney diseases (580–589) | 3,493 | (5.4) | 1,215 | (5.4) | 9,863 | (16.4) | 0.84 | (0.79–0.91)# | 2.96 | (2.83–3.10)# |
Hyperlipidemia (272) | 11,247 | (17.4) | 6,353 | (28.5) | 26,004 | (43.2) | 1.70 | (1.64–1.77)# | 2.63 | (2.56–2.71)# |
None of the above diseases | 7,745 | (12.0) | 841 | (3.8) | 113 | (0.2) | 0.28 | (0.25–0.31)# | 0.21 | (0.17–0.26)# |