Clinical effectiveness of pneumococcal vaccination against acute myocardial infarction and stroke in people over 60 years: the CAPAMIS study, one-year follow-up

Table 2 Incidence and Risk of hospitalization for community acquired pneumonia (CAP), acute myocardial infarction (AMI), ischaemic stroke and death from any cause among patients 60 years or older in relation to pneumococcal-vaccination status^a

	CAP	AMI	Ischaemic Stroke	Death from any cause
Number of event
Vaccinated	63	41	30	231
Unvaccinated	144	89	91	609
Unadjusted incidence rate per 1000 person-years
Vaccinated	7.1 (5.6-9.1)	4.6 (3.4-6.3)	3.4 (2.4-4.9)	26.1 (23.0-29.7)
Unvaccinated	8.2 (7.0-9.7)	5.1 (4.1-6.2)	5.2 (4.2-6.4)	34.6 (32.0-37.5)
Unadjusted hazard ratio for all subjects	0.87	0.91	0.66	0.75
(95% CI)	(0.65-1.17)	(0.63-1.32)	(0.43-0.99)	(0.65-0.88)
p value	0.368	0.637	0.046	< 0.001
Age, gender adjusted hazard ratio	0.87	0.90	0.66	0.79
(95% CI)	(0.65-1.17)	(0.62-1.30)	(0.44-1.00)	(0.68-0.91)
p value	0.354	0.582	0.049	0.002
	^b	^c	^d	^e
Multivariate hazard ratio	0.85	0.83	0.65	0.88
(95% CI)	(0.62-1.15)	(0.56-1.22)	(0.42-0.99)	(0.75-1.03)
p value	0.287	0.347	0.048	0.118

^a Hazard ratios were for vaccinated subjects as compared with unvaccinated subjects.
^b Adjusted for age, sex, number of outpatient visits in prior year, influenza vaccination in prior year, chronic pulmonary disease, chronic heart disease, smoking and nursing-home resident.
^c Adjusted for age, sex, number of outpatient visits in prior year, influenza vaccination in prior year, history of coronary artery disease, chronic heart disease, diabetes mellitus, hypercholesterolemia, smoking (confounder) and nursing-home resident.
^d Adjusted for age, sex, number of outpatient visits in prior year, influenza vaccination in prior year, history of coronary artery disease, history of stroke, smoking (confounder) and nursing-home resident.
^e Adjusted for age, sex, number of outpatient visits in prior year, influenza vaccination in prior year, chronic pulmonary disease, chronic heart disease, diabetes mellitus, cancer, chronic nephropaty, dementia, hypertension, hypercholesterolemia, obesity, smoking, and nursing home-resident.

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