|  | Univariate | Multivariate | ||||||
---|---|---|---|---|---|---|---|---|---|
 |  | No metabolic comorbidity | With metabolic comorbidity | No metabolic comorbidity | With metabolic comorbidity | ||||
 |  | Coefficient (95% CI) | P-value | Coefficient (95% CI) | P-value | Coefficient (95% CI) | P-value | Coefficient (95% CI) | P-value |
BMI category | Underweight | -0.051 (-0.084, -0.018) | 0.002 | -0.167 (-0.275, -.059) | 0.002 | -0.036 (-0.069, -0.004) | 0.027 | -0.141 (-0.245, -0.037) | 0.008 |
 | Normal-weight* | - | - | - | - | - | - | - | - |
 | Overweight | 0.008 (-0.000, 0.016) | 0.059 | 0.032 (0.004, 0.060) | 0.023 | 0.001 (-0.008, 0.009) | 0.900 | 0.026 (-0.002, 0.053) | 0.064 |
 | Obese | -0.012 (-0.022, -0.002) | 0.015 | -0.012 (-0.041, 0.015) | 0.380 | -0.016 (-0.026, -0.006) | 0.001 | -0.015 (-0.043, 0.013) | 0.290 |
 | Morbidly obese | -0.054(-0.079, -0.029) | < 0.001 | -0.085 (-0.137, -0.034) | 0.001 | -0.045 (-0.069, -0.020) | < 0.001 | -0.077 (-0.128, -0.026) | 0.003 |
Age (yrs) | 20-44 | 0.002 (-0.005, 0.010) | 0.500 | 0.001 (-0.036, 0.039) | 0.924 | 0.005 (-0.002, 0.013) | 0.190 | 0.007 (-0.030, 0.043) | 0.714 |
 | 45-64 | - | - | - | - | - | - | - | - |
 | ≥ 65 | -0.007 (-0.018, 0.003) | 0.191 | 0.004 (-0.016, 0.025) | 0.663 | -0.009 (-0.020, 0.002) | 0.106 | 0.004 (-0.017, 0.024) | 0.718 |
Sex | Male* | - | - | - | - | - | - | - | - |
 | Female | -0.020 (-0.028, -0.013) | < 0.001 | -0.009 (-0.029, 0.010) | 0.357 | -0.020 (-0.027, -0.013) | < 0. 001 | -0.005 (-0.025, 0.015) | 0.629 |
Deprivation quintiles | Â | Â | Â | Â | Â | Â | Â | Â | |
 | 1(Least deprived)* | - | - | - | - | - | - | - | - |
 | 2 | -0.012 (-0.023, -0.001) | 0.030 | -0.016(-0.048, 0.015) | 0.313 | -0.008 (-0.019, 0.002) | 0.132 | -0.009 (-0.040, 0.021) | 0.546 |
 | 3 | -0.026 (-0.037, -0.015) | < 0.001 | -0.053(-0.085, -0.021) | 0.001 | -0.019 (-0.030, -0.008) | 0.001 | -0.036 (-0.068, -0.004) | 0.027 |
 | 4 | -0.036 (-0.047, -0.024) | < 0.001 | -0.070(-0.103, -0.038) | < 0.001 | -0.026 (-0.038, -0.015) | < 0.001 | -0.050 (-0.082, -0.017) | 0.003 |
 | 5(Most deprived) | -0.070 (-0.082, -0.058) | < 0.001 | -0.117(-0.150, -0.084) | < 0.001 | -0.052 (-0.064, -0.040) | < 0.001 | -0.084 (-0.117, -0.051) | < 0.001 |
Smoking status | Never smoker* | - | - | - | - | - | - | - | - |
 | Ex-smoker | -0.012 (-0.021, -0.004) | 0.005 | -0.031 (-0.053, -0.009) | 0.006 | -0.008 (-0.016, 0.001) | 0.095 | -0.031 (-0.053, -0.009) | 0.006 |
 | Current smoker | -0.051 (-0.060, -0.042) | < 0.001 | -0.085 (-0.113, -0.058) | < 0.001 | -0.041 (-0.050, -0.032) | < 0.001 | -0.067 (-0.095, -0.038) | < 0.001 |
Drinking status | Never drinker* | - | - | - | - | - | - | - | - |
 | Ex-drinker | -0.058 (-0.083, -0.033) | < 0.001 | -0.066 (-0.118, -0.013) | 0.014 | -0.050 (-0.075, -0.026) | < 0.001 | -0.043 (-0.094, 0.008) | 0.098 |
 | Sensible drinker‡ | 0.010 (-0.008, 0.028) | 0.281 | 0.033 (-0.002, 0.069) | 0.067 | 0.003 (-0.014, 0.021) | 0.710 | 0.032 (-0.02, 0.067) | 0.068 |
 | Excessive drinker | 0.005 (-0.014, 0.024) | 0.623 | 0.056 (0.015, 0.097) | 0.007 | -0.001 (-0.020, 0.018) | 0.925 | 0.052 (0.010, 0.093) | 0.014 |
 | Missing | -0.059 (-0.136, 0.018) | 0.133 | 0.029 (-0.186, 0.244) | 0.793 | -0.054 (-0.130, 0.021) | 0.156 | 0.033 (-0.173, 0.239) | 0.754 |