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Table 1 Quality assessment of trials of aspirin alone in high-risk pregnancies for prevention of preeclampsia

From: Impact of interventions to prevent and manage preeclampsia and eclampsia on stillbirths

  Quality Assessment Summary of Findings
     Directness No of events  
No of studies (ref) Design Limitations Consistency Generalizability to population of interest Generalizability to intervention of interest Intervention Control Relative Risk (95% CI)
Stillbirths: LOW outcome specific quality
21 RCT High non-compliance rate, Small sample size, Placebo not used, Not double-blinded. Consistent; Low heterogeneity (p=0.62); Results statistically insignificant 1 study in developing country Yes 113 95 1.15 (0.88, 1.49)
Perinatal mortality: MODERATE/LOW outcome specific quality
13 RCT Low compliance; Small sample size Consistent; Low heterogeneity (p=0.39); Results statistically insignificant 3 studies in developing countries Yes 187 209 0.89 (0.74, 1.08)