Table 1 Quality assessment of trials of aspirin alone in high-risk pregnancies for prevention of preeclampsia
From: Impact of interventions to prevent and manage preeclampsia and eclampsia on stillbirths
| Â | Quality Assessment | Summary of Findings | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Directness | No of events | Â | ||
No of studies (ref) | Design | Limitations | Consistency | Generalizability to population of interest | Generalizability to intervention of interest | Intervention | Control | Relative Risk (95% CI) |
Stillbirths: LOW outcome specific quality | ||||||||
21 | RCT | High non-compliance rate, Small sample size, Placebo not used, Not double-blinded. | Consistent; Low heterogeneity (p=0.62); Results statistically insignificant | 1 study in developing country | Yes | 113 | 95 | 1.15 (0.88, 1.49) |
Perinatal mortality: MODERATE/LOW outcome specific quality | ||||||||
13 | RCT | Low compliance; Small sample size | Consistent; Low heterogeneity (p=0.39); Results statistically insignificant | 3 studies in developing countries | Yes | 187 | 209 | 0.89 (0.74, 1.08) |