Table 1 Quality assessment of trials of multiple micronutrient supplementation for maternal and pregnancy outcomes (Multiple micronutrients versus iron folate)
From: Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes
| Â | Quality Assessment | Summary of Findings | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Directness | No of events | Â | ||
No of studies (ref) | Design | Limitations | Consistency | Generalizability to population of interest | Generalizability to intervention of interest | Intervention | Control | Relative Risk (95% CI) |
Maternal Anaemia: High outcome specific quality | ||||||||
4 | cRCT/RCT | Some – high loss to follow-up and inadequate power (-0.5) | Heterogeneity in the meta-analysis = 50%. 2/4 studies showing benefit (-0.5) | All in developing countries | Generalizable | 351 | 336 | 1.03 (0.87 - 1.22), random model a |
Small-for-gestational age: High outcome specific quality | ||||||||
14 | cRCT/RCT | Some – high loss to follow-up, inadequate power, missing data (compliance), one study with a co-intervention (-0.5) | Consistent with 13/14 studies showing benefit | All in developing countries | Generalizable | 2289 | 2494 | 0.91 (0.86, 0.96), fixed model a |
Neonatal mortality: High outcome specific quality | ||||||||
9 | cRCT/RCT | Some - inadequate power of the studies (-0.5) | 7/9 studies giving a risk ratio of greater than 1 | All in developing countries | Generalizable | 558 | 513 | 1.05 (0.92, 1.19), fixed model a |