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Table 1 Quality assessment of trials of multiple micronutrient supplementation for maternal and pregnancy outcomes (Multiple micronutrients versus iron folate)

From: Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes

  Quality Assessment Summary of Findings
     Directness No of events  
No of studies (ref) Design Limitations Consistency Generalizability to population of interest Generalizability to intervention of interest Intervention Control Relative Risk (95% CI)
Maternal Anaemia: High outcome specific quality
4 cRCT/RCT Some – high loss to follow-up and inadequate power (-0.5) Heterogeneity in the meta-analysis = 50%. 2/4 studies showing benefit (-0.5) All in developing countries Generalizable 351 336 1.03 (0.87 - 1.22), random model a
Small-for-gestational age: High outcome specific quality
14 cRCT/RCT Some – high loss to follow-up, inadequate power, missing data (compliance), one study with a co-intervention (-0.5) Consistent with 13/14 studies showing benefit All in developing countries Generalizable 2289 2494 0.91 (0.86, 0.96), fixed model a
Neonatal mortality: High outcome specific quality
9 cRCT/RCT Some - inadequate power of the studies (-0.5) 7/9 studies giving a risk ratio of greater than 1 All in developing countries Generalizable 558 513 1.05 (0.92, 1.19), fixed model a
  1. a = generic inverse variance