From: Effect of case management on neonatal mortality due to sepsis and pneumonia
Ref and year | Country | Setting | Study design | Therapy given | Other interventions in package | Coverage of antibiotic case mx (% of those who need it) | Intervention group (N/D) | Control group (N/D) | Effect size RR (95% CI) |
---|---|---|---|---|---|---|---|---|---|
Bang 1999[9] | India | Rural | Non-randomized concurrent control study | Gentamicin IM and cotrimoxazole | Comprehensive perinatal care package including trained TBAs, VHWs undertaking >6 home visits, targeting of small babies for extra support, comm. mobilization for healthy home behaviors etc. | Years 1996-97 85% 685/804 Years 1997-98 93% 913/979 | 54/1783* | 113/2048* | 0.56 (0.41-0.77) |
Bhandari 1996[13] | India | Periurban/ urban | Observational | Cephalexin PO and amikacin IM | None | N/A | 124/2007 Age group =1-2 mths | None | No effect size can be calculated CFR= 3.3% |
Baqui 2008[12] | Bangladesh | Rural | Cluster randomized trial | Procaine penicillin and gentamicin | Birth and newborn-care preparedness postnatal home visits for newborns assessment on 1,3,7 days of birth. Referral when needed | 41% estimated from adequacy surveys | 82/2812 | 125/2872 | 0.66 (0.47-0.93) |
Baqui 2009[11] | Bangladesh | Rural | Observational ** | Procaine penicillin and gentamicin | Referral for very severe disease or possible very severe disease with multiple signs, by CHWs to government subdistrict hospitals. If the family was unable to comply with referral, the CHWs treated local skin and umbilical cord infections with gentian violet and made follow up visits to reassess the infant. | N/A | 9/204 | 24/112 | 0.22 (0.07-0.71) CFR=4.4% |