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Table 6 Summary of community-based studies including injectable antibiotics for case management of neonatal sepsis (observational, quasi experimental, and RCT)

From: Effect of case management on neonatal mortality due to sepsis and pneumonia

Ref and year Country Setting Study design Therapy given Other interventions in package Coverage of antibiotic case mx (% of those who need it) Intervention group (N/D) Control group (N/D) Effect size RR (95% CI)
Bang 1999[9] India Rural Non-randomized concurrent control study Gentamicin IM and cotrimoxazole Comprehensive perinatal care package including trained TBAs, VHWs undertaking >6 home visits, targeting of small babies for extra support, comm. mobilization for healthy home behaviors etc. Years 1996-97 85% 685/804
Years 1997-98 93% 913/979
54/1783* 113/2048* 0.56
(0.41-0.77)
Bhandari 1996[13] India Periurban/ urban Observational Cephalexin PO and amikacin IM None N/A 124/2007 Age group =1-2 mths None No effect size can be calculated CFR= 3.3%
Baqui 2008[12] Bangladesh Rural Cluster randomized trial Procaine penicillin and gentamicin Birth and newborn-care preparedness postnatal home visits for newborns assessment on 1,3,7 days of birth. Referral when needed 41% estimated from adequacy surveys 82/2812 125/2872 0.66
(0.47-0.93)
Baqui 2009[11] Bangladesh Rural Observational ** Procaine penicillin and gentamicin Referral for very severe disease or possible very severe disease with multiple signs, by CHWs to government subdistrict hospitals. If the family was unable to comply with referral, the CHWs treated local skin and umbilical cord infections with gentian violet and made follow up visits to reassess the infant. N/A 9/204 24/112 0.22
(0.07-0.71)
CFR=4.4%
  1. * Combined data from years 2 and 3 of trial i.e. 1996-1997 and 1997-1998.
  2. **Observational data on individual infants evaluated during the cluster randomized trial by Baqui et al. Control group is families unable to comply with referral and were not offered treatment with injectable antibiotics at home.