Table 4 GRADE assessment of studies of case management on cause specific neonatal mortality due to neonatal sepsis
From: Effect of case management on neonatal mortality due to sepsis and pneumonia
| Â | Quality Assessment | Summary of Findings | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | No. of Events | Effect | ||
No. of studies | Design | Limitations | Consistency | Generalizability to Population of Interest | Generalizability of the Intervention of interest | Intervention | Control | Relative Risk (95% CI) |
Mortality Sepsis – community based oral antibiotic studies | ||||||||
No studies identified | ||||||||
Mortality Sepsis – community based injectable antibiotic studies | ||||||||
2 | Observational | 1 study has no control group | Yes: both show low CFRs (3.3%, 4.4%) | Yes, both studies were done in high neonatal mortality regions. | Direct | 133/2211 | N/A | N/A |
1 | Non randomized - concurrent control trial | Change in sepsis specific mortality rate in intervention and control areas is not given | The results of this study were consistent with the RCT | Yes, study was done in a high neonatal mortality region. | Indirect | 54/1783 | 113/2048 | 0.56 (0.41-0.77) |
1 | RCT | Sepsis specific reduction in mortality not given | Reported similar results as study above | Yes, study was done in a high neonatal mortality region. | Indirect | 82/2812 | 125/2872 | 0.22 (0.07-0.71) CFR=4.4% |
Mortality Sepsis/Meningitis - case management in hospitals | ||||||||
55 | All observational study designs | All observational with varied study setting, from high-income to low-income countries. In low-income countries self-selecting populations because most births happen at community level. | CFR range from 67 to 6.7% | *NMR LEVEL5= 5 studies NMR LEVEL4=17 studies NMR LEVEL 3= 5 studies NMR LEVEL2=5 studies NMR LEVEL1=22 studies Multi country=1 | In countries with high skilled attendance hospital data generalizable to all population. But in low-income countries, hospital data not given as most births at home | N/A | N/A | N/A |