Author | Country | Study design | Intervention definition | Simultaneous Interventions | Intervention Coverage | Outcomes: Definition | Preterm vs. Intrapartum Death | N (Births) A = control B = comparison | Effect Size RR/OR (95% CI) |
---|---|---|---|---|---|---|---|---|---|
Pratinidhi et al, 1985[50] | Pune, India | Before-and-after | CHW training in basic resuscitation with mouth to mouth | Management of low birth weight, preterm, feeding, illness, cord cutting, feeding, nutrition; | 80% of home births received CHW care; 75% of births at home | 1) NMR; 2) PMR | Not stated | A) 1444; B) 1546 | 1) RR 0.75 2) RR 0.98 |
Daga SR et al, 1991[51] | Maharashtra, India | Before-and-after, no control | TBA training in basic resuscitation with mouth-to-mouth breathing | Management of low birth weight, hypothermia; transport and referral of high risk babies to hospital | TBAs attended 90% of deliveries | 1) NMR; 2) PMR; 3) SBR | Not stated | A) 321; B) 660 | 1) RR 0.59 (0.32-1.09); 2) RR 0.39 (0.21-0.69); 3) RR 0.49 (0.16, 1.50) |
Kumar R et a; 1998[55] | Haryana, India | Quasi-experimental | Advanced TBA training modern resuscitation with bag mask ventilation and mucus extractor | NS | TBAs delivered 92% of babies at home; | 1) Asphyxia mortality (Verbal Autopsy); 2) PMR | Combined "not breathing" | A) 964; B) 884 | 1) RR 0.30 (0.11-0.81) 2) RR 0.82 (0.56-1.19) |
Gadichiroli, India | Quasi-experimental | 1) 1996-1999: CHW+TBA attend deliveries together, basic resuscitation with tube-mask; 2) 1999-2003: Bag mask. Refresher training every 2 months. | Community treatment of suspected neonatal sepsis, essential newborn care | VHWs attended 84% of deliveries | 1) Asphyxia mortality (Verbal autopsy) 2) NMR 3) PMR 4) SBR 5) ENMR | Combined "not breathing" [Failure to breathe at 1, 5 min] | Before-after comparison A) 763 (95-6); B) 5510 (96-03) QE comparison A)1108 B) 979 | 1) RR 0.35 (0.15-0.78)a 2) RR 0.41 (0.26-0.66)b 3) RR 0.50 (0.35-0.71)b 4) RR 0.58 (0.36-0.93)b 5) RR 0.44 (0.27-0.73)b | |
Ariawan I, et al 2006[54] | Cirebon, Indonesia | Before-and-after, no control | Community mid-wife training in resuscitation with tube-mask, refresher training 3, 6, 9 month and VCD refresher video; training in "post-resuscitation" care | Not stated | 60% of asphyxia cases managed by midwives; uncertain coverage rate | 1) Asphyxia mortality (Verbal autopsy); 2) NMR; 3) SBR | Not stated | A) est 44,000; B) est 44,000 | 1) RR 0.39 (0.31-0.48) 2) RR 0.60 (0.53-0.68) 3) RR 0.39 (0.31-0.48) |
Carlo W et al 2010[52] | Argentina, DR Congo, Guatemala, India, Pakistan, Zambia | Before-and-after ENC; cluster RCT for NRP training | Training of community birth attendants (TBAs, nurses, midwives, and physicians) in WHO Essential Newborn Care, including basic resuscitation with bag-mask ventilation | Clean delivery, thermal protection, breastfeeding, kangaroo care | 78% of births attended by community birth attendant after ENC training | 1) PMR 2) SBR 3) ENMR | BW < 1500 g excluded | A) 22,626; B) 35,017 | 1) RR 0.85 (0.70-1.02) 2) RR 0.69 (0.54-0.88) 3) RR 0.99 (0.81-1.22) |
Gill C et al 2011[53] | Zambia | Cluster RCT | TBA Training in modified neonatal resuscitation program (NRP) w/facemask; competence assessments with refresher trainings every 3-4 mos. | Thermal care, Facilitated referral for presumptive neonatal sepsis (amoxicillin and referral) | Undetermined | 1) NMR 2) Day 1 mortality 3) Asphyxia NMR (Verbal autopsy) 4)PMR | Single cause assigned by VA "asphyxia" or "preterm" | A) 1920 B) 1517 | 1) aRR 0.55, (0.33-0.90) 2) aRR 0.40, (0.19-.83) 3) aRR 0.37 (0.17-0.81) 4) aRR 0.72 (0.51-1.00) |
Azad K et al 2011 [73] | Bangladesh | Cluster RCT, factorial design | Intervention arm: TBATraining neonatal resuscitation with bag-valve mask, with subsequent retraining; Control: TBA Training in mouth-to-mouth resuscitation | Intervention and control: Clean delivery, danger signs, emergency preparedness, facility referral. Women's participatory groups in half of clusters | Intervention Coverage: 22% of home deliveries attended by trained TBA; Control 19% by trained TBA | 1) ENMR | Not stated | A) 13195 B) 12519 | 1) 0.95 (0.75-1.21) |