Table 5 Weibull survival model with random effects in 2131 children on antiretroviral therapy (ART).
Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
HR* | CI (95%)** | P | aHR | CI (95%)** | P | |
Sex | ||||||
Boys | 1 | - | - | 1 | - | - |
Girls | 1.0 | 0.8-1.3 | 0.72 | 1.0 | 0.8-1.2 | 0.78 |
Age at ART initiation | ||||||
10 years and plus | 1 | - | - | 1 | - | - |
[5-10] years | 0.9 | 0.6-1.2 | 0.32 | 0.9 | 0.7-1.3 | 0.56 |
[3-5] years | 0.8 | 0.5-1.2 | 0.22 | 0.9 | 0.6-1.3 | 0.52 |
[1-3] years | 1.3 | 0.9-1.8 | 0.10 | 1.1 | 0.8-1.6 | 0.34 |
< 12 months | 1.4 | 0.6-2.9 | 0.36 | 1.1 | 0.5-2.4 | 0.66 |
ART regimen at baseline | ||||||
2 NRTI+1 NNRTI | 1 | - | - | 1 | ||
2 NRTI+1 IP | 0.7 | 0.5-0.9 | 0.01 | 0.9 | 0.7-1.2 | 0.62 |
Other | 0.6 | 0.2-1.5 | 0.24 | 1.0 | 0.4-2.5 | 0.98 |
Clinical stage at ART initiation | ||||||
A, B or I, II, III | 1 | - | - | 1 | - | - |
AIDS or IV | 2.6 | 2.0-3.5 | < 0.01 | 2.3 | 1.7-3.0 | < 0.01 |
Unknown | 1.3 | 0.8-2.1 | 0.21 | 1.4 | 0.9-2.3 | 0.15 |
% CD4 at ART initiation | ||||||
≥ 15% | 1 | - | - | 1 | - | - |
< 15% | 2.1 | 1.4.3.2 | < 0.01 | 1.9 | 1.3-2.9 | < 0.01 |
Missing | 1.5 | 0.9-2.5 | 0.07 | 1.7 | 1.1-2.8 | 0.03 |
Year of ART initiation | ||||||
≤ 2004 | 1 | - | - | 1 | - | - |
2005 | 2.0 | 1.5-2.7 | < 0.01 | 1.7 | 1.3-2.4 | < 0.01 |
≥ 2006 | 3.5 | 2.6-4.6 | < 0.01 | 3.0 | 2.2-4.0 | < 0.01 |
Cotrimoxazole status at ART initiation | ||||||
No | 1 | - | - | 1 | - | - |
Yes | 1.2 | 0.7-1.8 | 0.43 | 0.9 | 0.6-1.4 | 0.63 |
Missing | 0.6 | 0.2-1.8 | 0.32 | 0.4 | 0.1-1.5 | 0.16 |